Published online Nov 6, 2015. doi: 10.5527/wjn.v4.i5.480
Peer-review started: May 30, 2015
First decision: June 18, 2015
Revised: September 25, 2015
Accepted: October 16, 2015
Article in press: October 19, 2015
Published online: November 6, 2015
Core tip: Acute kidney injury (AKI) due to renal cortical necrosis (RCN) is rare in developed countries with reported incidence of less than 2% of all cases of acute renal failure. In contrast, its incidence is higher in developing countries ranging between 6%-7% of all causes of acute renal failure (ARF). Pregnancy related complications are the most common cause of RCN. With improved health care, wider availability of dialysis, and marked decline in septic abortion, the incidence and severity of RCN has decreased in developing countries in recent years. RCN accounts for 3% of all causes of AKI in our recent study. The current incidence of RCN in obstetrical AKI was 1.44% in 2003-2014. The most common cause of RCN is haemolytic uremic syndrome among non-obstetric patients and puerperal sepsis is the leading cause of RCN in pregnant patients. The strategy involving prevention and effective management of haemorrhagic and septic complications of pregnancy will further reduce the RCN incidence in pregnant patients in developing countries.