Prakash J, Singh VP. Changing picture of renal cortical necrosis in acute kidney injury in developing country. World J Nephrol 2015; 4(5): 480-486 [PMID: 26558184 DOI: 10.5527/wjn.v4.i5.480]
Corresponding Author of This Article
Dr. Jai Prakash, MD, FRCP, Professor and Head, Department of Nephrology, Institute of Medical Sciences, Banaras Hindu University, Pandit Madan Mohan Malviya Rd, Varanasi 221005, Uttar Pradesh, India. jprakash53@gmail.com
Research Domain of This Article
Urology & Nephrology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Nephrol. Nov 6, 2015; 4(5): 480-486 Published online Nov 6, 2015. doi: 10.5527/wjn.v4.i5.480
Changing picture of renal cortical necrosis in acute kidney injury in developing country
Jai Prakash, Vijay Pratap Singh
Jai Prakash, Vijay Pratap Singh, Department of Nephrology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, India
Author contributions: Prakash J and Singh VP equally contributed to this work.
Conflict-of-interest statement: Dr. Jai Prakash and I declare that there is no conflict of interest with respect to commercial, personal, political, intellectual or religious factors in the preparation of manuscript entitled “Changing picture of renal cortical necrosis in acute kidney injury in developing country”. Further, I have not received fund from pharmacological industries or any other funding agencies for the manuscript No. 20233 submitted for consideration of publication in the World journal of Nephrology.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Jai Prakash, MD, FRCP, Professor and Head, Department of Nephrology, Institute of Medical Sciences, Banaras Hindu University, Pandit Madan Mohan Malviya Rd, Varanasi 221005, Uttar Pradesh, India. jprakash53@gmail.com
Telephone: +91-542-2575508 Fax: +91-542-2367568
Received: May 29, 2015 Peer-review started: May 30, 2015 First decision: June 18, 2015 Revised: September 25, 2015 Accepted: October 16, 2015 Article in press: October 19, 2015 Published online: November 6, 2015
Core Tip
Core tip: Acute kidney injury (AKI) due to renal cortical necrosis (RCN) is rare in developed countries with reported incidence of less than 2% of all cases of acute renal failure. In contrast, its incidence is higher in developing countries ranging between 6%-7% of all causes of acute renal failure (ARF). Pregnancy related complications are the most common cause of RCN. With improved health care, wider availability of dialysis, and marked decline in septic abortion, the incidence and severity of RCN has decreased in developing countries in recent years. RCN accounts for 3% of all causes of AKI in our recent study. The current incidence of RCN in obstetrical AKI was 1.44% in 2003-2014. The most common cause of RCN is haemolytic uremic syndrome among non-obstetric patients and puerperal sepsis is the leading cause of RCN in pregnant patients. The strategy involving prevention and effective management of haemorrhagic and septic complications of pregnancy will further reduce the RCN incidence in pregnant patients in developing countries.
