Published online Sep 6, 2015. doi: 10.5527/wjn.v4.i4.468
Peer-review started: June 2, 2015
First decision: June 18, 2015
Revised: August 17, 2015
Accepted: August 30, 2015
Article in press: August 31, 2015
Published online: September 6, 2015
Core tip: Autosomal dominant polycystic kidney disease (ADPKD), the most frequent cause of genetic kidney disease affecting approximately 4 to 7 million individuals worldwide (7%-15% of patients on renal replacement therapy), is a systemic disorder mainly involving the kidney but cysts can also occur in other organs such as the liver, pancreas and arachnoid membrane. This paper discusses radiological evaluation of ADPKD, necessity for screening for intracranial aneurysms and current treatment strategies include reducing: cyclic adenosine monophosphate levels, cell proliferation and fluid secretion. It further discusses the role of surgery in managing ADPKD patients and highlights areas of new research.