Published online Sep 6, 2015. doi: 10.5527/wjn.v4.i4.455
Peer-review started: June 23, 2015
First decision: August 4, 2015
Revised: August 24, 2015
Accepted: August 30, 2015
Article in press: August 31, 2015
Published online: September 6, 2015
Core tip: For few glomerular diseases a new pathogenetic pathway has been recognized in the recent years as happened for the immunoglobulin A (IgA) nephropathy. Finding in the genetics allowed identifying several loci putative for the disease progression. Spectrometry mass studies and 3 dimension studies have allowed bettering clarifying the molecules involved at glomerular level. Molecular studies of the mesangium allowed identifying new receptors responsible for the IgA immune complexes deposition and for the binding to the mesangial structure. Finally molecular and cellular studies opened new ways to understanding the link and the cross-talk between the glomeruli and the tubulointerstitial structure.