Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Nephrol. May 6, 2015; 4(2): 223-229
Published online May 6, 2015. doi: 10.5527/wjn.v4.i2.223
Impact of obesity on kidney function and blood pressure in children
Wei Ding, Wai W Cheung, Robert H Mak
Wei Ding, Wai W Cheung, Robert H Mak, Department of Pediatrics, Rady Children’s Hospital, University of California, San Diego, CA 92093-0634, United States
Wei Ding, Division of Nephrology, the Fifth People’s Hospital of Shanghai, Fudan University, Shanghai 200000, China
Author contributions: Ding W reviewed the literature and wrote the draft; all authors edited and commented on the final draft of the manuscript.
Supported by The National Institute of Health, Nos. NIDDK U01DK-3-012 and R24HD050837 (Mak RH).
Conflict-of-interest: The authors have no conflicts of interest to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Robert H Mak, MD, PhD, Department of Pediatrics, Rady Children’s Hospital, University of California, 9500 Gilman Drive, MC0634, La Jolla, San Diego, CA 92093-0634, United States.
Telephone: +1-858-8226717 Fax: +1-858-8226776
Received: November 26, 2014
Peer-review started: November 26, 2014
First decision: December 12, 2014
Revised: February 12, 2015
Accepted: March 4, 2015
Article in press: March 6, 2015
Published online: May 6, 2015
Core Tip

Core tip: Excess weight gain appears to be a major risk factor for chronic kidney disease and hypertension. The potential mechanisms involve insulin resistance, inflammation, renal renin-angiotensin-aldosterone hyperactivity, and sympathetic nervous system hyperactivity. Increased awareness is needed in children for early diagnosis and implementation of prevention and treatment measures.