Published online May 6, 2015. doi: 10.5527/wjn.v4.i2.185
Peer-review started: August 21, 2014
First decision: September 28, 2014
Revised: December 19, 2014
Accepted: December 29, 2014
Article in press: December 31, 2014
Published online: May 6, 2015
Core tip: Recent advances suggest that glomerular haematuria may be a negative prognostic factor for renal function outcome. A more fragile and easily ruptured glomerular filtration barrier (GFB) may be responsible for glomerular bleeding. Several factors have been associated to this pathogenic process, including: (1) genetic alteration of GFB components, leading to a more fragile and easily ruptured GFB structure; (2) aberrant deposition of toxic molecules in the GFB; and (3) enhanced inflammatory response, as reported in autoimmune diseases, infections, or primary glomerulonephritis. In this review we fully describe these pathological mechanisms, with special interest in haematuric diseases and their renal morphological findings.