Roles of the (pro)renin receptor in the kidney

doi:10.5527/wjn.v3.i4.302

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Nov 6, 2014 (publication date) through Apr 18, 2024

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World Journal of Nephrology

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2220-6124

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Nephrol. Nov 6, 2014; 3(4): 302-307
Published online Nov 6, 2014. doi: 10.5527/wjn.v3.i4.302

Roles of the (pro)renin receptor in the kidney

Yoichi Oshima, Satoshi Morimoto, Atsuhiro Ichihara

Yoichi Oshima, Satoshi Morimoto, Atsuhiro Ichihara, Department of Medicine II, Endocrinology and Hypertension, Tokyo Women’s Medical University, Shinjuku-ku, Tokyo 162-8666, Japan

Author contributions: Oshima Y collected the literature, wrote the paper and created the figures; Morimoto S corrected and revised the paper; Ichihara A also checked the manuscript and provided financial support.

Correspondence to: Satoshi Morimoto, MD, PhD, Associate Professor, Department of Medicine II, Endocrinology and Hypertension, Tokyo Women’s Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan. smorimoto@endm.twmu.ac.jp

Telephone: +81-3-33538111 Fax: +81-3-52697327

Received: June 25, 2014
Revised: September 14, 2014
Accepted: October 14, 2014
Published online: November 6, 2014

Core Tip

Core tip: Prorenin receptor (PRR) has shown its multi-functionality in at least four different aspects. In this review, the roles of PRR in kidney physiology and diabetic conditions as well as recent findings regarding a soluble form of PRR are discussed. Additionally, we propose the possible mechanism concerning diabetic nephropathy as “trade-off hypothesis” from a PRR point of view.