Onuigbo MAC, Agbasi N. Chronic kidney disease prediction is an inexact science: The concept of “progressors” and “nonprogressors”. World J Nephrol 2014; 3(3): 31-49 [PMID: 25332895 DOI: 10.5527/wjn.v3.i3.31]
Corresponding Author of This Article
Macaulay Amechi Chukwukadibia Onuigbo, MD, MSc, FWACP, FASN, MBA, Department of Nephrology, Mayo Clinic Health System, 1221 Whipple Street, Eau Claire, WI 54702, Unites States. onuigbo.macaulay@mayo.edu
Research Domain of This Article
Medicine, General & Internal
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Macaulay Amechi Chukwukadibia Onuigbo, Mayo Clinic College of Medicine, Rochester, MN 55905, United States
Macaulay Amechi Chukwukadibia Onuigbo, Department of Nephrology, Mayo Clinic Health System, Eau Claire, WI 54702, United States
Nneoma Agbasi, North East London NHS Foundation Trust, Ilford IG3 8XJ, United Kingdom
Author contributions: Onuigbo MAC contributed to conception, design, acquisition of data, data analysis, interpretation of data, drafting the article and final approval of manuscript; Agbasi N contributed to critically revise for important intellectual content, final approval of manuscript.
Correspondence to: Macaulay Amechi Chukwukadibia Onuigbo, MD, MSc, FWACP, FASN, MBA, Department of Nephrology, Mayo Clinic Health System, 1221 Whipple Street, Eau Claire, WI 54702, Unites States. onuigbo.macaulay@mayo.edu
Telephone: +1-715-8383891 Fax: +1-715-8381946
Received: April 13, 2014 Revised: June 13, 2014 Accepted: July 25, 2014 Published online: August 6, 2014
Core Tip
Core tip: In 2002, the National Kidney Foundation established a novel chronic kidney disease (CKD) staging paradigm. In 2012, the authoritative United States Preventative Task Force questioned the validity of asymptomatic CKD screening. The American Society of Nephrology and the American College of Physicians have opposite recommendations regarding this controversy. We examined the evidence-base and limitations of CKD staging. Furthermore, we show clinical evidence of pitfalls of the current CKD staging model and the failings of current CKD prediction models. We called for more research into CKD to end stage renal disease translations including the impact of acute kidney injury on this continuum. CKD care and prognostication must be individualized.
