Chronic kidney disease in geriatric patients: Estimating glomerular filtration rate in older patients with comorbidities

doi:10.5527/wjn.v14.i2.105803

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Jun 25, 2025 (publication date) through May 20, 2025

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World Journal of Nephrology

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2220-6124

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Letter to the Editor

World J Nephrol. Jun 25, 2025; 14(2): 105803
Published online Jun 25, 2025. doi: 10.5527/wjn.v14.i2.105803

Chronic kidney disease in geriatric patients: Estimating glomerular filtration rate in older patients with comorbidities

Guido Gembillo, Luca Soraci, Domenico Santoro

Guido Gembillo, Unit of Nephrology and Dialysis, Department of Clinical and Experimental Medicine, University of Messina, Messina 98125, Sicilia, Italy

Luca Soraci, Unit of Geriatric Medicine, Italian National Research Center on Aging (IRCCS INRCA), Cosenza 87100, Calabria, Italy

Domenico Santoro, Unit of Nephrology and Dialysis, AOU "G. Martino", University of Messina, Messina 98125, Sicilia, Italy

Co-first authors: Guido Gembillo and Luca Soraci.

Author contributions: Gembillo G and Soraci L contribute equally to this study as co-first authors; Gembillo G, Soraci L and Santoro D collaborated on this manuscript.

Conflict-of-interest statement: We declare no conflict of interest.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Guido Gembillo, MD, PhD, Assistant Professor, Unit of Nephrology and Dialysis, Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, 1, Messina 98125, Sicilia, Italy. guidogembillo@live.it

Received: February 7, 2025
Revised: March 7, 2025
Accepted: March 21, 2025
Published online: June 25, 2025
Processing time: 61 Days and 16.4 Hours

Core Tip

Core Tip: Older people often battle with multiple health issues, such as diabetes, high blood pressure and heart disease, making treatment considerably more challenging, particularly if they have kidney problems. This specific cohort presents a meaningful diagnostic challenge in identifying kidney problems because of the large difficulty in differentiating normal aging from early chronic kidney disease. Accurate glomerular filtration rate estimation is important to prevent misdiagnosis, improper treatment and medication errors resulting from inaccurate calculations.