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World J Nephrol. Sep 25, 2021; 10(5): 76-87
Published online Sep 25, 2021. doi: 10.5527/wjn.v10.i5.76
Serum phosphate and chronic kidney and cardiovascular disease: Phosphorus potential implications in general population
Vaia D Raikou
Vaia D Raikou, Department of Nephrology, Doctors’ Hospital, Athens 11257, Greece
Author contributions: Raikou VD wrote this manuscript.
Conflict-of-interest statement: The author declares no conflict of interests.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Vaia D Raikou, PhD, Chief Doctor, Department of Nephrology, Doctors’ Hospital, 26 Kefallinias, Athens 11257, Greece. vraikou@med.uoa.gr
Received: February 27, 2021
Peer-review started: February 27, 2021
First decision: May 6, 2021
Revised: May 20, 2021
Accepted: July 23, 2021
Article in press: July 23, 2021
Published online: September 25, 2021
Core Tip

Core Tip: Disordered phosphorus homeostasis in chronic kidney diseases is associated with bad outcomes including cardiovascular morbidity/mortality and progression of renal dysfunction in end-stage of renal disease. Potential health consequences in cardiovascular and kidney disease could be developed in subjects with a high intake of dietary phosphorus despite the apparently normal renal function, due mainly to abnormalities in metabolism and in regulatory factors, rather than to serum phosphorus itself. The maintenance of serum phosphorus in normal range should be obtained.