Ndongo M, Nehemie LM, Coundoul B, Diouara AAM, Seck SM. Prevalence and outcomes of polycystic kidney disease in African populations: A systematic review. World J Nephrol 2024; 13(1): 90402 [PMID: 38596265 DOI: 10.5527/wjn.v13.i1.90402]
Corresponding Author of This Article
Modou Ndongo, MD, Doctor, Department of Nephrology and Dialysis, Regional Hospital of Kedougou, Dimboli, Route de Fongolimbi, Kedougou 26005, Senegal. ndongomodou@gmail.com
Research Domain of This Article
Urology & Nephrology
Article-Type of This Article
Systematic Reviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Modou Ndongo, Department of Nephrology and Dialysis, Regional Hospital of Kedougou, Kedougou 26005, Senegal
Lot Motoula Nehemie, Baratou Coundoul, Sidy Mohamed Seck, Department of Nephrology and Dialysis, Military Hospital of Ouakam, Dakar 28216, Senegal
Abou Abdallah Malick Diouara, Department of Chemical Engineering and Applied Biology, Polytechnic high School of Cheikh Anta Diop University, Dakar 5085, Senegal
Sidy Mohamed Seck, Department of Nephrology, Faculty of Health Sciences, University Gaston Berger, Saint-Louis 234, Senegal
Author contributions: Seck SM and Ndongo M designed the study and performed the research; Seck SM and Ndongo M analyzed the data and wrote the manuscript; Ndongo M, Nehemie LM, Coundoul B, Diouara AAM and Seck SM edited and reviewed the manuscript; the manuscript has been read and approved by all authors.
Conflict-of-interest statement: All authors have no conflict of interest to disclose for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Modou Ndongo, MD, Doctor, Department of Nephrology and Dialysis, Regional Hospital of Kedougou, Dimboli, Route de Fongolimbi, Kedougou 26005, Senegal. ndongomodou@gmail.com
Received: December 4, 2023 Peer-review started: December 4, 2023 First decision: December 28, 2023 Revised: January 3, 2024 Accepted: March 11, 2024 Article in press: March 11, 2024 Published online: March 25, 2024
ARTICLE HIGHLIGHTS
Research background
Polycystic kidney disease is known as the most common genetic cause of chronic kidney disease. Its natural evolution lead to end-stage kidney disease. However, unlike developed countries, clinical and prognosis outcomes data of the disease are lacking in African population.
Research motivation
Mapping the data of polycystosis in African population and emphasize the gap between data from international literature and those available in our specific population and outline points for further studies.
Research objectives
Describe the prevalence, clinical, and genetic aspects of polycystic kidney disease in an African population.
Research methods
A literature review and meta-analysis of available data were performed from January 2000 to September 2023 to identify reported data of prevalence, clinical manifestation, and genetics anomalies of patients with polycystic kidney disease in the continent.
Research results
A total of 943 patients with polycystic kidney disease were reported in the period of research but the real prevalence of the disease is not known in the continent. Most patients present with symptoms at diagnosis mainly kidney function impairment and abdominal mass. Nevertheless, the mean age at diagnosis is similar to the literature data. Genetic testing was not frequent, however, they showed a high proportion of new mutations.
Research conclusions
Most African patients with polycystic kidney disease present with severe symptoms and complications at diagnosis. A high proportion of new mutations were reported in this population particularly in the PKD1 gene.
Research perspectives
Further researches are needed to better assess the real prevalence of PKD and the spectrum of mutations in the continent.
