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World J Nephrol. Dec 6, 2012; 1(6): 160-165
Published online Dec 6, 2012. doi: 10.5527/wjn.v1.i6.160
Erectile dysfunction in hemodialysis: A systematic review
Ahmed El-Assmy
Ahmed El-Assmy, Urology and Nephrology Center, Mansoura University, Mansoura 35516, Egypt
Author contributions: El-Assmy A solely contributed to this manuscript.
Correspondence to: Ahmed El-Assmy, Associate Professor of Urology, Urology and Nephrology Center, Mansoura University, Mansoura 35516, Egypt.
Telephone: +20-50-2262222 Fax: +20-50-2263717
Received: August 19, 2011
Revised: June 12, 2012
Accepted: September 25, 2012
Published online: December 6, 2012

Men with chronic renal failure (CRF) on hemodialysis have been frequently associated with erectile dysfunction (ED), with an of between 20% to 87.7%. As a result of the multi-system disease processes present in many uremic men, it is apparent that the pathogenesis of ED is most probably multifactorial. Factors to be considered include peripheral vascular disease, neurogenic abnormalities, hormonal disturbances and medications used for treatment of conditions associated with CRF. These physiological abnormalities may be supplemented by significant psychological stresses and abnormalities resulting from chronic illness. Treatment must start with the determination and treatment of the underlying causes. In addition to psychological treatment, further lines of treatment of ED in CRF can be classified as 1st line (medical treatment which includes oral phosphodiesterase-5 inhibitors and hormone regulation), 2nd line (intracavernosal injection, vacuum constriction devices and alprostadil urethral suppositories) or 3rd line (surgical treatment). Renal transplantation improves the quality of life for some patients with CRF and subsequently it may improve erectile function in a significant number of them, however still there is high incidence of ED after transplantation.

Keywords: Erectile dysfunction, Haemodialysis, Risk factor, Treatment, Renal failure