Copyright ©The Author(s) 2023.
World J Virol. Mar 25, 2023; 12(2): 100-108
Published online Mar 25, 2023. doi: 10.5501/wjv.v12.i2.100
Table 1 Immune-mediated phenomena concerning the liver, following severe acute respiratory syndrome coronavirus 2 vaccination
Mechanism of injury
Liver antigens
Immune mediators
Molecular mimicrySLAAutoreactive antibodies
Cytotoxicity/Humoral responseS protein (membrane expression)Activated CD8 + clone/protective anti-S antibodies
Humoral responseACE-2 transmembrane receptorProtective anti-S antibodies
Immune complex depositionS protein (soluble)
Soluble ACE-2/ACE-2 ligand + S protein
“Bystander” toxicityActivated CD8 + clone
Loss of self-tolerance/FibrosisType I IFN
NLRP3 inflammasome activationLNPs
TLR-mediated innate immune responsemRNA