Uppala PK, Karanam SK, Kandra NV, Edhi S. Hantavirus infections: A growing global health concern. World J Virol 2026; 15(3): 120334 [DOI: 10.5501/wjv.120334]
Corresponding Author of This Article
Praveen Kumar Uppala, PhD, M.Pharm, Assistant Professor, Department of Pharmacology, Maharajah’s College of Pharmacy, Phool Baugh, Vizianagaram 535002, Andhra Pradesh, India. praveen.chintu32@gmail.com
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Virology
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review-article
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Uppala PK, Karanam SK, Kandra NV, Edhi S. Hantavirus infections: A growing global health concern. World J Virol 2026; 15(3): 120334 [DOI: 10.5501/wjv.120334]
World J Virol. Sep 25, 2026; 15(3): 120334 Published online Sep 25, 2026. doi: 10.5501/wjv.120334
Hantavirus infections: A growing global health concern
Praveen Kumar Uppala, Sita K Karanam, Naga Vishnu Kandra, Sandhya Edhi
Praveen Kumar Uppala, Department of Pharmacology, Maharajah’s College of Pharmacy, Vizianagaram 535002, Andhra Pradesh, India
Sita K Karanam, Department of Pharmaceutical Biotechnology, Maharajah’s College of Pharmacy, Vizianagaram 535002, Andhra Pradesh, India
Naga Vishnu Kandra, Department of Radiodiagnosis, Santhiram Medical College and General Hospital, Nandyal 518501, Andhra Pradesh, India
Sandhya Edhi, Department of Pharmacognosy, Andhra University College of Pharmaceutical Sciences, Visakhapatnam 530003, Andhra Pradesh, India
Author contributions: Uppala PK and Edhi S drafted the original manuscript; Karanam SK conducted the final revision and supervised the manuscript; Vishnu Kandra N performed the literature search; and all authors conceptualized and designed the study, participated in manuscript drafting, critically reviewed the manuscript, and approved the final submitted version.
AI contribution statement: AI tools were used only to generate Figures 2 and 3 using OpenAI’s ChatGPT image generation system (DALL·E) based on author-prepared scientific prompts. The authors reviewed, edited, and verified these figures for scientific accuracy. Figure 1 was prepared by the authors using publicly available scientific resources and was not AI-generated. AI was also used only for limited language refinement; all scientific interpretation, analysis, and final approval were completed by the authors.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Praveen Kumar Uppala, PhD, M.Pharm, Assistant Professor, Department of Pharmacology, Maharajah’s College of Pharmacy, Phool Baugh, Vizianagaram 535002, Andhra Pradesh, India. praveen.chintu32@gmail.com
Received: February 25, 2026 Revised: May 16, 2026 Accepted: September 17, 2026 Published online: September 25, 2026 Processing time: 206 Days and 2.2 Hours
Core Tip
Core Tip: Hantavirus infections represent an expanding global zoonotic threat characterized by high mortality rates and limited therapeutic options. This article provides an updated and integrated overview of hantavirus biology, epidemiology, clinical manifestations, diagnostic strategies, and emerging therapeutic approaches. Particular emphasis is placed on recent advances in molecular virology, RNA-based antiviral technologies, monoclonal antibody therapy, and next-generation vaccine platforms, including mRNA and DNA vaccines. By combining classical clinical perspectives with contemporary translational research, this review identifies key gaps in current knowledge and proposes future directions for surveillance, therapeutic development, and global preparedness.
