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Singh P, Khare R, Sharma K, Bhargava A, Negi SS. Alpha to JN.1 variants: SARS-CoV-2 genomic analysis unfolding its various lineages/sublineages evolved in Chhattisgarh, India from 2020 to 2024. World J Virol 2025; 14(2): 100001 [PMID: 40575649 DOI: 10.5501/wjv.v14.i2.100001]
Pushpendra Singh, Ruchi Khare, Kuldeep Sharma, Anudita Bhargava, Sanjay Singh Negi, Department of Microbiology, All India Institute of Medical Sciences, Raipur 492099, Chhattīsgarh, India
Author contributions: Negi SS, Singh P, Sharma K, and Bhargava A were responsible for conceptualization and contributed to the design and implementation of the research; Singh P, Khare R, and Negi SS were responsible for methodology and writing of the original draft; Sharma K, Negi SS, and Singh P were responsible for bioinformatics software analysis; Negi SS and Bhargava A were responsible for supervision and analyzed the data along with resources for the study; Singh P, Sharma K, and Khare R performed all experiments; All authors read and agreed to the published version of the manuscript, and the corresponding author had final responsibility for the decision to submit for publication.
Institutional review board statement: The submitted study was approved both from institutional ethical and research committee, AIIMS, Raipur (IEC/AIIMS/RPR/1453/2021).
Conflict-of-interest statement: The authors have no conflicts of interest regarding the publication of this article.
Data sharing statement: All genome sequences and associated metadata in this dataset are published in GISAID’s EpiCoV database. To view the contributors of each individual sequence with details such as accession number, virus name, collection date, originating lab and submitting lab and the list of authors, visit 10.55876/gis8.240227op (GISAID Identifier: EPI_SET_240227op).
Corresponding author: Sanjay Singh Negi, PhD, Professor, Department of Microbiology, All India Institute of Medical Sciences, Tatibandh, GE Road, Raipur 492099, Chhattīsgarh, India. negidr@aiimsraipur.edu.in
Received: August 5, 2024 Revised: December 30, 2024 Accepted: January 23, 2025 Published online: June 25, 2025 Processing time: 322 Days and 1 Hours
Core Tip
Core Tip: Chhattisgarh, a central state of India is still being affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 2019 infection in humans, even in 2024 after four years from the time of its first emergence in April, 2020. No specific report giving details of each and every variant with their mutational pattern evolved over these four years is available. This study has provided insight of evolutionary journey underwent by the virus to unravel SARS-CoV-2 Lineages circulating predominantly in Chhattisgarh at different time period along with genomic pattern of crucial mutations and their effect. The details of circulating lineages with their prevalence rate and mutational pattern would help the researchers and policy makers to update the vaccine strain for persisting its effectivity against new variants or providing baseline data for developing new therapeutics.
