Juneja D, Gupta A, Kataria S, Singh O. Role of high dose vitamin C in management of hospitalised COVID-19 patients: A minireview. World J Virol 2022; 11(5): 300-309 [PMID: 36188745 DOI: 10.5501/wjv.v11.i5.300]
Corresponding Author of This Article
Deven Juneja, DNB, FCCP, MBBS, Director, Institute of Critical Care Medicine, Max Super Speciality Hospital, 1 Press Enclave Road, Saket, New Delhi 110017, India. devenjuneja@gmail.com
Research Domain of This Article
Critical Care Medicine
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Deven Juneja, Anish Gupta, Sahil Kataria, Omender Singh, Institute of Critical Care Medicine, Max Super Speciality Hospital, Saket, New Delhi 110017, India
Author contributions: Juneja D, Gupta A, and Kataria S performed the majority of the writing, prepared the tables, and performed data accusation; Singh O provided the input in writing the paper and reviewed the manuscript.
Conflict-of-interest statement: There are no conflicts of interest to report.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Deven Juneja, DNB, FCCP, MBBS, Director, Institute of Critical Care Medicine, Max Super Speciality Hospital, 1 Press Enclave Road, Saket, New Delhi 110017, India. devenjuneja@gmail.com
Received: July 29, 2022 Peer-review started: July 29, 2022 First decision: August 22, 2022 Revised: August 22, 2022 Accepted: September 1, 2022 Article in press: September 1, 2022 Published online: September 25, 2022
Core Tip
Core Tip: Vitamin C has several biochemical effects including anti-oxidant, anti-inflammatory, immuno-modulatory, and anti-viral properties which could make it a possible low-risk, add on to the current therapeutic options for managing coronavirus disease 2019 (COVID-19) patients. As it is a water-soluble vitamin, even high doses have been shown to be safe and only rarely, complications have been reported. In the last couple of years, many case series, observational studies and even randomised control trials have been conducted to evaluate the role of vitamin C in COVID-19, but have shown conflicting results. Hence, as per the current clinical evidence, the role of vitamin C remains ambiguous and it cannot be recommended as a part of routine therapeutic regimen for managing COVID-19 patients.
