Published online May 25, 2021. doi: 10.5501/wjv.v10.i3.86
Peer-review started: January 28, 2021
First decision: February 24, 2021
Revised: March 10, 2021
Accepted: April 26, 2021
Article in press: April 26, 2021
Published online: May 25, 2021
Core Tip: With more than 100 million confirmed cases worldwide, hepatobiliary injury has been reported in many coronavirus disease 2019 (COVID-19) patients. The association between COVID-19 and hepatobiliary injury refers to any hepatobiliary damage during disease progression and treatment in COVID-19 patients with or without chronic liver diseases or common medications. Angiotensin-converting enzyme 2 receptor may be a significant factor in hepatobiliary derangement due to its high expression in cholangiocytes, and it is also an entry point of severe acute respiratory syndrome coronaviruses 2. Moreover, drug-induced liver injury and cytokine storm may be an added risk in severe clinical outcomes. Close monitoring of liver function in COVID-19 patients is mandatory.