Published online May 25, 2022. doi: 10.5501/wjv.v11.i3.144
Peer-review started: December 16, 2021
First decision: February 21, 2022
Revised: February 21, 2022
Accepted: April 26, 2022
Article in press: April 26, 2022
Published online: May 25, 2022
Processing time: 154 Days and 11.4 Hours
According to this study, each investigated variant altered the electrostatic interactions between the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor binding domain and the angiotensin-converting enzyme 2 (ACE2) receptor. The omicron variant showed the biggest alteration, followed by the delta and beta variants. This finding could back up the clinical observation that the omicron variant is more transmissible than the wild type and other SARS-CoV-2 variants.
Each studied variant affected the electrostatic interactions between the SARS-CoV-2 receptor binding domain and the ACE2 receptor. The omicron form, followed by the delta and beta variants, displays the most change. This could support the clinical finding that the omicron variant is more contagious than the wild type and other SARS-CoV-2 variants.
The authors conducted a study to see how mutations are associated with alterations of electrostatic interactions between receptor binding domain of SARS-CoV-2 with the ACE2 receptor.
The researchers investigated how mutations affect electrostatic interactions between the SARS-CoV-2 receptor binding domain and the ACE2 receptor. In this report, three important coronavirus disease 2019 variants, beta, delta, and omicron, were investigated.
There was a change of electrostatic interactions between the receptor binding domain of SARS-CoV-2 with the ACE2 receptor due to each studied variant compared to wild type. The most change was detected for the omicron variant, followed by delta variant and beta variant.
Our findings can support the clinical observation that the omicron variant has an increased transmissibility comparable to the wild type and other variants.
Our findings are consistent with the clinical observation that the omicron variation is more transmissible than the wild type and other variants.