Published online Sep 25, 2020. doi: 10.5501/wjv.v9.i3.27
Peer-review started: May 7, 2020
First decision: July 25, 2020
Revised: August 7, 2020
Accepted: August 24, 2020
Article in press: August 24, 2020
Published online: September 25, 2020
The pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has garnered the attention of scientists worldwide in the search for an effective treatment while also focusing on vaccine development. Several drugs have been used for the management of coronavirus disease 2019 (COVID-19), which has affected many hospitals and health centers worldwide. Statistically significant results are lacking on the effectiveness of the experimented drugs in reducing COVID-19 morbidity or mortality, as there are very few published randomized clinical trials. Despite this, the literature offers some material for study and reflection. This opinion review attempts to address three burning questions on COVID-19 treatment options. (1) What kind of studies are currently published or ongoing in the treatment of patients with COVID-19? (2) What drugs are currently described in the literature as options of treatment for patients affected by the infection? And (3) Are there specific clinical manifestations related to COVID-19 that can be treated with a customized and targeted therapy? By answering these questions, we wish to create a summary of current COVID-19 treatments and the anti-COVID-19 treatments proposed in the recent clinical trials developed in the last 3 mo, and to describe examples of clinical manifestations of the SARS-CoV-2 infection with a cause-related treatment.
Core Tip: The pandemic spread of coronavirus disease 2019 (COVID-19) has led to the need to standardize a therapeutic approach in order to offer the same indications for all patients admitted to the hospital admissions for severe acute respiratory syndrome coronavirus 2 infection. However, no specific drug or drug regimen has been approved for treatment. This opinion review describes the recent literature on this topic and summarizes the treatment strategies currently in use for COVID-19 related complications.