Gibellini D, Clò A, Morini S, Miserocchi A, Ponti C, Re MC. Effects of human immunodeficiency virus on the erythrocyte and megakaryocyte lineages. World J Virol 2013; 2(2): 91-101 [PMID: 24175233 DOI: 10.5501/wjv.v2.i2.91]
Corresponding Author of This Article
Dr. Davide Gibellini, Department of Haematology and Oncological Sciences, Microbiology Section, University of Bologna, St Orsola Hospital, Via Massarenti 9, 40138 Bologna, Italy. davide.gibellini@unibo.it
Research Domain of This Article
Virology
Article-Type of This Article
Topic Highlight
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World J Virol. May 12, 2013; 2(2): 91-101 Published online May 12, 2013. doi: 10.5501/wjv.v2.i2.91
Effects of human immunodeficiency virus on the erythrocyte and megakaryocyte lineages
Davide Gibellini, Alberto Clò, Silvia Morini, Anna Miserocchi, Cristina Ponti, Maria Carla Re
Davide Gibellini, Alberto Clò, Silvia Morini, Anna Miserocchi, Maria Carla Re, Department of Haematology and Oncological Sciences, Microbiology Section, University of Bologna, 40138 Bologna, Italy
Cristina Ponti, Department of Life Sciences, University of Trieste, 34127 Trieste, Italy
Maria Carla Re, Interuniversity Consortium, National Institute Biostructure and Biosystems, 00136 Rome, Italy
Author contributions: Gibellini D, Clò A, Morini S and Miserocchi A designed the paper and selected the references; Gibellini D, Ponti C and Carla Re M wrote the paper.
Supported by Funds from Fondazione Cassa di Risparmio Bologna, Italy, No. 2006.0035; Fondazione del Monte di Bologna e Ravenna, Italy, No. 376 bis; “AIDS projects” of the Italian Ministry of Health, No. 40H5; and Funds for Selected Research Topics of the University of Bologna and MURST 60%
Correspondence to: Dr. Davide Gibellini, Department of Haematology and Oncological Sciences, Microbiology Section, University of Bologna, St Orsola Hospital, Via Massarenti 9, 40138 Bologna, Italy. davide.gibellini@unibo.it
Telephone: +39-514-290927 Fax: +39-513-07397
Received: December 5, 2012 Revised: January 7, 2013 Accepted: January 11, 2013 Published online: May 12, 2013
Abstract
Anaemia and thrombocytopenia are haematological disorders that can be detected in many human immunodeficiency virus (HIV)-positive patients during the development of HIV infection. The progressive decline of erythrocytes and platelets plays an important role both in HIV disease progression and in the clinical and therapeutic management of HIV-positive patients. HIV-dependent impairment of the megakaryocyte and erythrocyte lineages is multifactorial and particularly affects survival, proliferation and differentiation of bone marrow (BM) CD34+ haematopoietic progenitor cells, the activity of BM stromal cells and the regulation of cytokine networks. In this review, we analyse the major HIV-related mechanisms that are involved in the genesis and development of the anaemia and thrombocytopenia observed in HIV positive patients.
