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©2012 Baishideng Publishing Group Co., Limited. All rights reserved.
Delivery strategies for novel vaccine formulations
Maria Trovato, Piergiuseppe De Berardinis, Institute of Protein Biochemistry, CNR, Naples 80131, Italy
Shelly J Krebs, Nancy L Haigwood, Division of Pathobiology and Immunology, Oregon National Primate Research Center, and Vaccine and Gene Therapy Institute, Oregon Health and Sciences University, Beaverton, OR 97006, United States
Author contributions: All authors contributed to this paper.
Supported by A grant from NIH (R01 A1074379) and FIRB project (n. RBLA033WJX) from the Italian Ministry of Research
Correspondence to: Piergiuseppe De Berardinis, PhD, Institute of Protein Biochemistry, C.NR, Naples 80131, Italy. p.deberardinis@ibp.cnr.it
Telephone: +39-81-6132566 Fax: +39-81-6132277
Received: July 13, 2011
Revised: September 16, 2011
Accepted: September 25, 2011
Published online: February 12, 2012
Revised: September 16, 2011
Accepted: September 25, 2011
Published online: February 12, 2012
Abstract
A major challenge in vaccine design is to identify antigen presentation and delivery systems capable of rapidly stimulating both the humoral and cellular components of the immune system to elicit a strong and sustained immunity against different viral isolates. Approaches to achieve this end involve live attenuated and inactivated virions, viral vectors, DNA, and protein subunits. This review reports the state of current antigen delivery, and focuses on two innovative systems recently established at our labs. These systems are the filamentous bacteriophage fd and an icosahedral scaffold formed by the acyltransferase component (E2 protein) of the pyruvate dehydrogenase complex of Bacillus stearothermophilus.
Keywords: Vaccines, Antigen presentation, Antigen delivery systems, Filamentous bacteriophage fd, E2 scaffold