Review
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Apr 24, 2017; 7(2): 117-128
Published online Apr 24, 2017. doi: 10.5500/wjt.v7.i2.117
Intra-islet endothelial cell and β-cell crosstalk: Implication for islet cell transplantation
Siddharth Narayanan, Gopalakrishnan Loganathan, Maheswaran Dhanasekaran, William Tucker, Ankit Patel, Venugopal Subhashree, SriPrakash Mokshagundam, Michael G Hughes, Stuart K Williams, Appakalai N Balamurugan
Siddharth Narayanan, Gopalakrishnan Loganathan, Maheswaran Dhanasekaran, William Tucker, Ankit Patel, SriPrakash Mokshagundam, Michael G Hughes, Stuart K Williams, Appakalai N Balamurugan, Clinical Islet Cell Laboratory, Center for Cellular Transplantation, Cardiovascular Innovation Institute, Department of Surgery, University of Louisville, Louisville, KY 40202, United States
Venugopal Subhashree, School of Biosciences and Technology, VIT University, Vellore 632014, India
Author contributions: All authors contributed to this paper.
Conflict-of-interest statement: None declared.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Appakalai N Balamurugan, PhD, Clinical Islet Cell Laboratory, Center for Cellular Transplantation, Cardiovascular Innovation Institute, Department of Surgery, University of Louisville, 302 E Muhammad Ali Blvd., Louisville, KY 40202, United States. bala.appakalai@louisville.edu
Telephone: +1-502-7947070 Fax: +1-502-8540558
Received: January 4, 2017
Peer-review started: January 7, 2017
First decision: February 17, 2017
Revised: February 28, 2017
Accepted: March 23, 2017
Article in press: March 24, 2017
Published online: April 24, 2017
Core Tip

Core tip: This review article summarizes recent developments in the cross-talk relationship between intra-islet endothelial cells and beta cells. The molecules involved in the signalling pathways can be potential targets for therapeutic strategies and islet transplantation.