Observational Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Dec 24, 2016; 6(4): 729-735
Published online Dec 24, 2016. doi: 10.5500/wjt.v6.i4.729
Persistent Epstein-Barr viral load in Epstein-Barr viral naïve pediatric heart transplant recipients: Risk of late-onset post-transplant lymphoproliferative disease
Bibhuti Das, Robert Morrow, Rong Huang, David Fixler
Bibhuti Das, David Fixler, Deptartment of Pediatrics, Children’s Medical Center, University of Texas Southwestern Medical Center, Dallas, TX 75235, United States
Robert Morrow, Rong Huang, Children’s Medical Center, Dallas, TX 75235, United States
Author contributions: All the authors contributed to the manuscript.
Institutional review board statement: University of Texas Southwestern Medical center and Children’s Medical Center, Dallas Institutional Review Board approved this study.
Informed consent statement: Patients were not required to give informed consent because of observational, retrospective nature of the study.
Conflict-of-interest statement: The authors of this manuscript have no conflicts of interest to disclose pertinent to this research.
Data sharing statement: No additional data available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Bibhuti Das, MD, Deptartment of Pediatrics, Children’s Medical Center, University of Texas Southwestern Medical Center, 1935 Medical District Dr, Dallas, TX 75235, United States. bdas99@hotmail.com
Telephone: +1-214-4566333 Fax: +1-214-4567758
Received: July 7, 2016
Peer-review started: July 12, 2016
First decision: September 12, 2016
Revised: October 5, 2016
Accepted: November 21, 2016
Article in press: November 23, 2016
Published online: December 24, 2016
Core Tip

Core tip: Post-transplant lymphoproliferative disorder (PTLD) after heart transplantation is a severe complication where there is still limited information is available. There are many publications on estimations of PTLD frequency in different settings and types of patient, as well as the factors associated with its appearance and prognosis. But, most studies do not take into account the length of follow-up which may be misleading given that patients are exposed to the risk of immunosuppression over a long period of follow-up. This study is unique that, it is a single center study span over a period of 18 years in which maintenance immunosuppression therapy and management of rejection episodes remained same throughout. Although, a single center study result cannot be generalized, however it adds to the existing literature for risk stratification of these patients based on whole blood Epstein-Barr virus (EBV) polymerase chain reaction (PCR) after accounting for the time since transplant and patients¡¯ pre-transplant EBV serostatus. This paper also highlights the risk of acute rejection after reduction or alteration in immunosuppression in patients with high EBV load by PCR without any effect on the occurrence of PTLD.