Russo FB, Cugola FR, Fernandes IR, Pignatari GC, Beltrão-Braga PCB. Induced pluripotent stem cells for modeling neurological disorders. World J Transplant 2015; 5(4): 209-221 [PMID: 26722648 DOI: 10.5500/wjt.v5.i4.209]
Corresponding Author of This Article
Patricia C B Beltrão-Braga, PhD, Assistant Professor, Stem Cell Lab, Department of Surgery, School of Veterinary Medicine, University of São Paulo, 87 Prof. Dr. Orlando Marques de Paiva Av., São Paulo 05508-270, Brazil. patriciacbbbraga@usp.br
Research Domain of This Article
Neurosciences
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Transplant. Dec 24, 2015; 5(4): 209-221 Published online Dec 24, 2015. doi: 10.5500/wjt.v5.i4.209
Induced pluripotent stem cells for modeling neurological disorders
Fabiele B Russo, Fernanda R Cugola, Isabella R Fernandes, Graciela C Pignatari, Patricia C B Beltrão-Braga
Fabiele B Russo, Fernanda R Cugola, Isabella R Fernandes, Graciela C Pignatari, Patricia C B Beltrão-Braga, Stem Cell Lab, Department of Surgery, School of Veterinary Medicine, University of São Paulo, São Paulo 05508-270, Brazil
Patricia C B Beltrão-Braga, Center for Cellular and Molecular Therapy (NETCEM), School of Medicine, University of São Paulo, São Paulo 01246-903, Brazil
Patricia C B Beltrão-Braga, Department of Obstetrics, School of Arts, Sciences and Humanities, University of São Paulo, São Paulo 03828-100, Brazil
Author contributions: All authors contributed to this manuscript, collecting data and writing.
Conflict-of-interest statement: All authors have no conflict of interest to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Patricia C B Beltrão-Braga, PhD, Assistant Professor, Stem Cell Lab, Department of Surgery, School of Veterinary Medicine, University of São Paulo, 87 Prof. Dr. Orlando Marques de Paiva Av., São Paulo 05508-270, Brazil. patriciacbbbraga@usp.br
Telephone: +55-11-30911417 Fax: +55-11-30917690
Received: June 29, 2015 Peer-review started: July 3, 2015 First decision: July 30, 2015 Revised: August 23, 2015 Accepted: September 25, 2015 Article in press: September 28, 2015 Published online: December 24, 2015
Core Tip
Core tip: Several diseases have been successfully modeled using induced pluripotent stem cell (iPSC) technology. Neurological disorders are frequent targets of iPSC-disease modeling for its ability to generate in vitro disease-relevant cell types from the central nervous system, such as neurons and glial cells. Patientspecific iPSC-derived neural cells can recapitulate the phenotypes of these diseases, unveiling mechanisms and providing drug screening platforms for novel therapeutic targets. Here, we review the accomplishments and the current progress achieved in human neurological disorders by using iPSC modeling for Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, spinal muscular atrophy, amyotrophic lateral sclerosis, duchenne muscular dystrophy, schizophrenia and autism spectrum disorders.
