Donohue CI, Mallett SV. Reducing transfusion requirements in liver transplantation. World J Transplant 2015; 5(4): 165-182 [PMID: 26722645 DOI: 10.5500/wjt.v5.i4.165]
Corresponding Author of This Article
Ciara I Donohue, MBChB, BSc, FRCA, Anaesthetic Registrar, Royal Free Perioperative Research Group (RoFPoR), Department of Anaesthesia, Royal Free London NHS Trust, Pond Street, Hampstead, London NW3 2QG, United Kingdom. ciara.donohue@nhs.net
Research Domain of This Article
Transplantation
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Transplant. Dec 24, 2015; 5(4): 165-182 Published online Dec 24, 2015. doi: 10.5500/wjt.v5.i4.165
Reducing transfusion requirements in liver transplantation
Ciara I Donohue, Susan V Mallett
Ciara I Donohue, Susan V Mallett, Royal Free Perioperative Research Group (RoFPoR), Department of Anaesthesia, Royal Free London NHS Trust, London NW3 2QG, United Kingdom
Author contributions: Donohue CI and Mallett SV contributed equally to this manuscript.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Ciara I Donohue, MBChB, BSc, FRCA, Anaesthetic Registrar, Royal Free Perioperative Research Group (RoFPoR), Department of Anaesthesia, Royal Free London NHS Trust, Pond Street, Hampstead, London NW3 2QG, United Kingdom. ciara.donohue@nhs.net
Telephone: +44-207-7945000
Received: June 29, 2015 Peer-review started: July 1, 2015 First decision: August 4, 2015 Revised: October 21, 2015 Accepted: November 23, 2015 Article in press: November 25, 2015 Published online: December 24, 2015
Core Tip
Core tip: Liver transplantation (LT) was historically associated with massive blood loss. Many factors have contributed to the decline in bleeding and transfusion in the past two decades including refinement of surgical techniques, anaesthetic management and the use of point of care guided goal-directed haemostatic therapies. Increasing awareness of the adverse associations of allogenic transfusion has driven the quest for transfusion-free transplantation. Increasing use of marginal grafts and transplantation of sicker recipients will continue to challenge perioperative care and transfusion practice. Inter-institutional variability suggests a current lack of clear guidance and limited application of the principles of patient blood management to LT.
