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World J Transplant. Dec 24, 2014; 4(4): 299-305
Published online Dec 24, 2014. doi: 10.5500/wjt.v4.i4.299
Published online Dec 24, 2014. doi: 10.5500/wjt.v4.i4.299
1400W reduces ischemia reperfusion injury in an ex-vivo porcine model of the donation after circulatory death kidney donor
Sarah A Hosgood, Phillip J Yates, Michael L Nicholson, Department of Infection, Immunity and Inflammation, Transplant Group, University of Leicester, LE5 4PW Leicester, United Kingdom
Sarah A Hosgood, Michael L Nicholson, Leicester General Hospital, University Hospitals of Leicester, LE5 4PW Leicester, United Kingdom
Author contributions: Hosgood SA, Yates PJ and Nicholson ML designed the study; Hosgood SA and Yates PJ carried out the experiments; Hosgood SA and Yates PJ analysed the data; Hosgood SA and Yates PJ wrote the manuscript; Nicholson ML revised the manuscript and approved the final version.
Correspondence to: Dr. Sarah A Hosgood, Department of Infection, Immunity and Inflammation, Transplant Group.University of Leicester, Gwendolen Road, LE5 4PW Leicester, United Kingdom. sarahhosgood@hotmail.com
Telephone: +44-116-2584658 Fax: +44-116-2490064
Received: May 28, 2014
Revised: July 8, 2014
Accepted: October 31, 2014
Published online: December 24, 2014
Revised: July 8, 2014
Accepted: October 31, 2014
Published online: December 24, 2014
Core Tip
Core tip: It is important to examine the effects of therapies that can reduce ischemia reperfusion injury particularly in donation after circulatory death donor kidneys. The biological role of inducible nitric oxide synthase (iNOS) is somewhat controversial. This study uses a large animal ex vivo model to assess the effects of 1400W, an iNOS inhibitor. The model provides a functional assessment of each kidney, providing a close simulation to clinical transplantation. The study found that 1400W improved early renal function and reduced oxidative stress.