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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Sep 18, 2025; 15(3): 103015
Published online Sep 18, 2025. doi: 10.5500/wjt.v15.i3.103015
Published online Sep 18, 2025. doi: 10.5500/wjt.v15.i3.103015
Impact of donor obesity on paediatric liver transplantation; current evidence and potentials for graft pool expansion
Amr Alnagar, Department of General Surgery, University Hospitals of Birmingham, Birmingham B13 0QB, United Kingdom
Ahmed Amgad, Faculty of Medicine, Helwan University, Cairo 4034572, Al Qāhirah, Egypt
Tassos Grammatikopoulos, Department of Paediatric Liver, GI and Nutrition, King's College Hospital, London SE5 9RS, United Kingdom
Eirini Kyrana, Roger Williams Institute of Liver Studies, King's College London, London SE5 9NT, United Kingdom
Co-first authors: Amr Alnagar and Ahmed Amgad.
Author contributions: Alnagar A and Amgad A designed the study, conducted the literature review, and wrote the manuscript draft; they contribute equally to this study as co-first authors; Grammatikopoulos T and Kyrana E performed the critical revision and final drafting of the manuscript.
Conflict-of-interest statement: The authors have no conflicts of interest to declare that are relevant to the content of this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Amr Alnagar, PhD, Department of General Surgery, University Hospitals of Birmingham, 6 Chamberlain Road, Birmingham B13 0QB, United Kingdom.
Received: November 5, 2024
Revised: March 12, 2025
Accepted: March 26, 2025
Published online: September 18, 2025
Processing time: 164 Days and 12.2 Hours
Revised: March 12, 2025
Accepted: March 26, 2025
Published online: September 18, 2025
Processing time: 164 Days and 12.2 Hours
Core Tip
Core Tip: Paediatrics liver transplantation is primarily dependent on graft availability. Currently there is a gap between is the available grafts and number of children on transplant waiting list resulting in graft shortage. Grafts from obese donors has the risk of hepatic steatosis which could negatively impact transplantation outcomes. Donor obesity should not substitute steatosis work-up as the latter is viewed as independent predictor of graft dysfunction. New strategies to optimize grafts before transplantation might within limits mitigate the risk of using grafts from obese donors.