Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Sep 18, 2021; 11(9): 372-387
Published online Sep 18, 2021. doi: 10.5500/wjt.v11.i9.372
Journey of a patient with scleroderma from renal failure up to kidney transplantation
Fedaey Abbas, Mohsen El Kossi, Ihab Sakr Shaheen, Ajay Sharma, Ahmed Halawa
Fedaey Abbas, Department of Nephrology, Faculty of Health and Science, University of Liverpool, Institute of Learning and Teaching, School of Medicine, Liverpool L69 3GB, United Kingdom
Mohsen El Kossi, Doncaster Renal Unit, Doncaster Royal Infirmary, Doncaster DN2 5LT, United Kingdom
Ihab Sakr Shaheen, Department of Paediatric Nephrology, St James’s University Hospital, Glasgow G51 4TF, United Kingdom
Ajay Sharma, Department of Transplant Surgery, Royal Liverpool University Hospital, Liverpool L7 8XP, United Kingdom
Ahmed Halawa, Department of Transplant Surgery, Sheffield Teaching Hospital, Sheffield S5 7AU, United Kingdom
Author contributions: Abbas F designed the study, data collection, writing the manuscript; El Kossi M, Shaheen IS and Sharma A reviewed and edited the manuscript; Halawa A conceptualized and designed the study, supervised the data collection, and reviewed and edited the manuscript.
Conflict-of-interest statement: Fedaey Abbas is an employee (under contract) of MOD, Kuwait.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Ahmed Halawa, FRCS, MD, Senior Lecturer, Surgeon, Department of Transplant Surgery, Sheffield Teaching Hospital, Herries Road, Sheffield S5 7AU, United Kingdom.
Received: January 29, 2021
Peer-review started: January 29, 2021
First decision: April 6, 2021
Revised: April 10, 2021
Accepted: August 19, 2021
Article in press: August 19, 2021
Published online: September 18, 2021
Core Tip

Core Tip: The current progress in the management of systemic sclerosis has its impact on improving patient’s survival and quality of life. Patients developed scleroderma renal crisis have greatly managed after commencing angiotensin converting enzyme inhibitors. Moreover, scleroderma patient with kidney failure has a marvelous therapeutic option receiving a kidney transplant with a greatly improved extrarenal manifestations. However, patients with end stage kidney failure, maintained on regular dialysis, should have enough period permitting renal recovery before attempting the transplant procedures. This duration may be actually extended up to two years. Patients with scleroderma may show the highest rate of renal recovery among dialysis patients.