Copyright
©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Oct 18, 2020; 10(10): 283-290
Published online Oct 18, 2020. doi: 10.5500/wjt.v10.i10.283
Published online Oct 18, 2020. doi: 10.5500/wjt.v10.i10.283
Combined liver and kidney transplantation in children and long-term outcome
Randula Ranawaka, Department of Paediatrics, Faculty of Medicine, University of Colombo and Lady Ridgeway Hospital for Children, Colombo 0094, Sri Lanka
Kavinda Dayasiri, Department of Paediatrics, Base Hospital Mahaoya, Mahaoya 0094, Sri Lanka
Manoji Gamage, Department of Clinical Nutrition, Lady Ridgeway Hospital for Children, Colombo 0094, Sri Lanka
Author contributions: Ranawaka R, Dayasiri K, Gamage M performed literature survey; Ranawaka R, Dayasiri K, Gamage M wrote the manuscript; Ranawaka R edited the final version of the manuscript. All authors read and approved the final version of the manuscript.
Conflict-of-interest statement: No conflict of interest to be declared.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Randula Ranawaka, MBBS, MD, Chief Physician, Senior Lecturer, Senior Researcher, Department of Paediatrics, Faculty of Medicine, University of Colombo and Lady Ridgeway Hospital for Children, Kynsey Road, Colombo 0094, Sri Lanka. rrandula@yahoo.com
Received: July 8, 2020
Peer-review started: July 8, 2020
First decision: August 22, 2020
Revised: September 17, 2020
Accepted: September 25, 2020
Article in press: September 25, 2020
Published online: October 18, 2020
Peer-review started: July 8, 2020
First decision: August 22, 2020
Revised: September 17, 2020
Accepted: September 25, 2020
Article in press: September 25, 2020
Published online: October 18, 2020
Core Tip
Core Tip: Combined liver-kidney transplantation (CLKT) is a complex surgical procedure which is increasingly performed for a number of indications, especially primary hyperoxaluria type 1 and autosomal recessive polycystic kidney disease. In CLKT, the early mortality is mostly related to infections and surgical complications of the liver graft. On the other hand, chronic complications with liver graft are fairly rare, and the liver protects the kidney allograft from rejection, which results in stable function and long term survival of the renal allograft. Long-term outcomes are promising in children who had CLKT with good overall long-term survival rates when performed in experienced centers with expertise.