Bukhari MA, Alhomayani FK, Al Eid HS, Al-Malki NK, Alotaibi ME, Hussein MA, Habibullah ZN. Is peri-transplant blood transfusion associated with worse transplant outcomes? A retrospective study. World J Transplant 2023; 13(4): 157-168 [PMID: 37388388 DOI: 10.5500/wjt.v13.i4.157]
Corresponding Author of This Article
Muhammad A Bukhari, MD, Attending Doctor, Multi-organ Transplantation Center, King Abdullah Medical City, Third Ring Road, Makkah 29123, Saudi Arabia. bukhary5354@hotmail.com
Research Domain of This Article
Transplantation
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Transplant. Jun 18, 2023; 13(4): 157-168 Published online Jun 18, 2023. doi: 10.5500/wjt.v13.i4.157
Is peri-transplant blood transfusion associated with worse transplant outcomes? A retrospective study
Muhammad A Bukhari, Faisal K Alhomayani, Hala S Al Eid, Najla K Al-Malki, Mutlaq Eidah Alotaibi, Mohamed A Hussein, Zainab N Habibullah
Muhammad A Bukhari, Zainab N Habibullah, Multi-organ Transplantation Center, King Abdullah Medical City, Makkah 29123, Saudi Arabia
Faisal K Alhomayani, Department of Internal Medicine, College of Medicine, Taif University, Taif 23611, Saudi Arabia
Hala S Al Eid, Department of Pharmacy, Alhada Armed Forces Hospital, Taif 29123, Saudi Arabia
Najla K Al-Malki, Mutlaq Eidah Alotaibi, Mohamed A Hussein, Department of Nephrology and Transplantation, Alhada Armed Forces Hospital, Taif 29123, Saudi Arabia
Author contributions: All the co-authors contributed in data collection, writing, editing, literature review and designing the study.
Institutional review board statement: Approved by the hospital's IRB at AL-Hada Armed Forces Hospital, No. REC 2023-719.
Informed consent statement: Signed informed consent wasn’t required for this manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Consent was not obtained but the presented data are anonymized and risk of identification is low.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Muhammad A Bukhari, MD, Attending Doctor, Multi-organ Transplantation Center, King Abdullah Medical City, Third Ring Road, Makkah 29123, Saudi Arabia. bukhary5354@hotmail.com
Received: March 17, 2023 Peer-review started: March 17, 2023 First decision: April 13, 2023 Revised: April 18, 2023 Accepted: May 4, 2023 Article in press: May 4, 2023 Published online: June 18, 2023
Abstract
BACKGROUND
Blood transfusion is common during the peri-transplantation period. The incidence of immunological reactions to blood transfusion after kidney transplantation and their consequences on graft outcomes have not been extensively studied.
AIM
To examine the risk of graft rejection and loss in patients who received blood transfusion in the immediate peri-transplantation period.
METHODS
We conducted a single-center retrospective cohort study of 105 kidney recipients, among them 54 patients received leukodepleted blood transfusion at our center between January 2017 and March 2020.
RESULTS
This study included 105 kidney recipients, of which 80% kidneys were from living-related donors, 14% from living-unrelated donors, and 6% from deceased donors. Living-related donors were mostly first-degree relatives (74.5%), while the rest were second-degree relatives. The patients were divided into transfusion (n = 54) and non-transfusion (n = 51) groups. The average hemoglobin level at which blood transfusion was commenced was 7.4 ± 0.9 mg/dL. There were no differences between the groups in terms of rejection rates, graft loss, or death. During the study period, there was no significant difference in creatinine level progression between the two groups. Delayed graft function was higher in the transfusion group; however, this finding was not statistically significant. A high number of transfused packed red blood cells was significantly associated with increased creatinine levels at the end of the study.
CONCLUSION
Leukodepleted blood transfusion was not associated with a higher risk of rejection, graft loss, or death in kidney transplant recipients.
Core Tip: Blood transpfusion in patient undergoing kidney transplantation has long been avoided for the fear for the potential risk of reciepient's immunization and potential rejection. This study addresses the risks of peri-transplantation outcomes of blood transfusion.
