Monitoring osteoporosis therapy: Can FRAX help assessing success or failure in achieving treatment goals?

Figure 1 The 10-year hip fracture probability (the World Health Organization fracture risk assessment tool) in relation to incident fracture groups at baseline, 2 and 5-year. (Mean 10-year fracture risk probability are shown on top of each column). NS: Not significant; HS: Highly significant, P < 0.01 vs baseline.

Figure 2 The 10-year major osteoporosis fracture probability (the World Health Organization fracture risk assessment tool) in relation to incident fracture groups at baseline, 2 and 5-year. (Mean 10-year fracture risk probability is shown on top of each column). S: Significant; HS: Highly significant, P < 0.01 vs baseline.

Figure 3 Total proximal femur bone mineral density in relation to the incidence of major osteoporosis fractures (mean bone mineral content are shown on top of each column). F. BMD: Femur bone mineral density; NS: Not significant; HS: Highly significant.

Figure 4 ROC curve displaying discriminating ability of 10 years the World Health Organization fracture risk assessment tool major osteoporosis and hip fracture probability at 2 years in prediction of fracture. A and B: At 2 years [The AUC for he World Health Organization fracture risk assessment tool (FRAX) major osteoporosis fracture: 0.916 and FRAX hip fracture 0.94]; C: At 5 years [The AUC for he World Health Organization fracture risk assessment tool (FRAX) major osteoporosis fracture: 0.748 and FRAX hip fracture 0.992]. AUC: Area under the curve; ROC: Receiver operating characteristic; MjOP: Major osteoporosis fracture.