Published online Mar 12, 2016. doi: 10.5499/wjr.v6.i1.9
Peer-review started: May 26, 2015
First decision: June 18, 2015
Revised: July 9, 2015
Accepted: November 3, 2015
Article in press: November 4, 2015
Published online: March 12, 2016
Core tip: Leptin is an adipokine well known for its role in metabolism and body weight regulation. More recently, it has gained recognition as a potential contributor to the pathogenesis of inflammatory disorders. Numerous studies reveal elevated leptin levels in rheumatoid arthritis patients. Similarly, a link between severity of osteoarthritis and leptin levels has been suggested. At the same time, little research on the role of leptin in the pathogenesis of psoriatic arthritis has been conducted. Further investigation on these relationships could provide for better-targeted treatment of these rheumatic diseases and their systemic manifestations.