Published online Jul 12, 2015. doi: 10.5499/wjr.v5.i2.50
Peer-review started: January 24, 2015
First decision: February 7, 2015
Revised: April 29, 2015
Accepted: May 5, 2015
Article in press: May 6, 2015
Published online: July 12, 2015
Biologic agents have ushered a new era in the treatment of inflammatory rheumatic diseases. In recent years, several biologic agents have been approved by food and drug administration and have significantly improved outcomes for patients with immune mediated inflammatory disorders including rheumatic and inflammatory bowel diseases. The most common used biologic therapeutic agents are tumor necrosis factor inhibitors (etanercept, infliximab, adalimumab, certolizumab pegol, and golimumab), an interleukin (IL)-6 inhibitor (tocilizumab), an IL-1 receptor antagonist (anakinra), an anti-CD-20 antibody (rituximab), and a T cell co-stimulation modulator (abatacept). Their use during pregnancy has been controversial because of absence of controlled studies which have enrolled pregnant women. This brief overview provides published data on use of biologic agents for the treatment of rheumatic diseases in pregnancy.
Core tip: Biologic agents are increasingly being used in the treatment of rheumatic diseases. This article presents published data on use of biologic agents in pregnant women with rheumatic diseases.