Post-traumatic stress disorder risk and brain-derived neurotrophic factor Val66Met

Table 1 Brain derived neurotrophic factor and common psychiatric disorders

Mental disorders	Results and references
Schizophrenia	Polymorphisms and BDNF[39]
	The Val66Met allele association[40]
	The TrkB receptor decreased in the hippocampus[41]
	Up-[41] and down[42] regulated BDNF in the frontal cortices
Major depressive disorder	Antidepressant increases BDNF levels[43]
	BDNF protein increased in the NAc[44]
	The decreased prefrontal cortex is correlated with decreased BDNF and TrkB levels[45,46]
	BDNF dose-dependently decreases 5HT uptake[47]
	Unclear whether BDNF polymorphisms contribute to expression of MDD symptoms or antidepressant efficacy[48,49]
Bipolar	Both lithium and valproic acid increase BDNF expression in corticolimbic brain[40]
	BDNF protein levels decreased in post mortem hippocampal tissue[40]
	Serum BDNF levels decreased[49]
	The V66M BDNF allele strongly correlated to BD[35,50]
PTSD	PTSD risk associated with BDNF Val66Met and BDNF overexpression[15]
	Blood BDNF levels and PTSD[4,15,18-21]

NAc: Nucleus accumbens; BDNF: Brain derived neurotrophic factor; MDD: Microgram per square decimeter per day; PTSD: Post-traumatic stress disorder.