Systematic Reviews
Copyright ©The Author(s) 2015.
World J Psychiatr. Mar 22, 2015; 5(1): 154-159
Published online Mar 22, 2015. doi: 10.5498/wjp.v5.i1.154
Table 1 Characteristics of the included studies
Ref.SampleAge (yr)Matched forIllness duration (yr)MedicationBDNF measurement
Jockers-Scherübl et al[9]157 FEP31.8Age, genderNot reportedDrug naïveSerum
72 Ctl32.3
Zakharyan et al[10]25 FEP25.3 ± 9.2Age, gender18.4 ± 7.2Drug naïvePlasma
105 Ctl37.3 ± 11.3
Murphy et al[11]15 FEP18.6 ± 3.3Age, genderNot reportedQuetiapineSerum
15 Ctl18.5 ± 3.1
Sotiropoulou et al[12]50 FEP29.84 ± 8.20Age, genderNot reportedDrug naïveSerum
50 Ctl31.36 ± 7.96
Ruiz de Azua et al[13]47 FEP24.3 ± 8.5Age, gender, education levelNot reportedDrug naïve, Rsp, OlzPlasma
47 Ctl24.0 ± 8.8
Yoshimura et al[14]50 FEP30.8 ± 5.3Age, genderNot reportedApzPlasma
50 Ctl32.3 ± 7.1
Rizos et al[5]20 FEP30.8 ± 10.5Age, gender, education level, employmentNot reportedDrug naïveSerum
21 Ctl34.0 ± 4.7
González-Pinto et al[15]18 FEP24.39 ± 6.53Age, genderNot reportedDrug naïve1Plasma
18 Ctl25.19 ± 5.95
Rizos et al[16]37 FEP26.81 ± 9.22Age, genderNot reportedDrug naïveSerum
22 Ctl26.59 ± 4.47
Jindal et al[17]41 FEP22.40 ± 5.47Age, genderNot reportedDrug naïveSerum
41 Ctl22.31 ± 5.67
Goto et al[18]18 FEP29 ± 11Age, gender9.4 ± 6.8Drug naïve, Rsp/Olz/ApzSerum
18 Ctl30 ± 11
Pillai et al[19]34 FEP32.19 ± 8.74Age, genderNot reportedDrug naïvePlasma
36 Ctl38.30 ± 1.26
Rizos et al[20]31 FEP26.81 ± 9.22Age, gender, education level, employmentNot reportedDrug naïveSerum
22 Ctl26.81 ± 9.22
Chen da et al[21]88 FEP29.2 ± 9.6Age, gender, education level, smoking23.4 ± 19.1Drug naïveSerum
90 Ctl29.8 ± 9.8
Rizos et al[22]14 FEP25.4 ± 5.8Age, gender, education level, employmentNot reportedDrug naïveSerum
15 Ctl26.6 ± 5.0
Buckley et al[23]15 FEP21.00 ± 8.83Age, gender25.2 ± 33.0Drug naïvePlasma
14 Ctl25.00 ± 5.72
Palomino et al[24]48 FEP23.7 ± 1.0Age, genderNot reportedAtypical, mood stabilizersPlasma
43 Ctl25.5 ± 0.8
Pirildar et al[25]22 FEP27.81 ± 9.54Age, gender15.2 ± 13.0Drug naïve1Serum
22 Ctl25.7 ± 5.8
Table 2 Basal levels of brain-derived neurotrophic factor
Ref.FEP (ng/mL)Controls (ng/mL)ResultsEffect size d (CI)
Jockers-Scherübl et al[9]13.1 ± 5.913.2 ± 0.2No difference0.10 (-0.18-0.38)
Zakharyan et al[10]0.176 ± 0.0140.24 ± 0.3↓ in FEP1.21 (0.75-1.67)
Murphy et al[11]Missing dataMissing dataNo difference-
Sotiropoulou et al[12]12620 ± 186014520 ± 2180↓ in FEP0.64 (0.23-1.04)
Ruiz de Azua et al[13]6.09 ± 3.709.19 ± 4.21↓ in FEP0.66 (0.24-1.07)
Yoshimura et al[14]0.7 ± 0.4Missing data↓ in FEP0.43 (0.03-0.82)
Rizos et al[5]9.76 ± 4.6115.33 ± 6.34↓ in FEP0.99 (0.34-1.64)
González-Pinto et al[15]4.09 ± 2.315.80 ± 2.66↓ in FEP-
Rizos et al[16]18.87 ± 8.2329.20 ± 7.73↓ in FEP0.72 (0.17-1.26)
Jindal et al[17]0.09 ± 0.030.117 ± 0.04↓ in FEP0.54 (0.10-0.99)
Goto et al[18]Missing dataMissing dataNo difference0.38 (-0.28-1.04)
Pillai et al[19]Missing dataMissing data↓ in FEP0.53 (0.05-1.00)
Rizos et al[20]Missing dataMissing data↓ in FEP-
Chen da et al[21]9.0 ± 4.212.1 ± 2.2↓ in FEP0.92 (0.61-1.23)
Rizos et al[22]23.90 ± 5.9930.00 ± 8.43↓ in FEP0.83 (0.07-1.59)
Buckley et al[23]0.017 ± 0.0030.049 ± 0.007↓ in FEP1.37 (0.56-2.18)
Palomino et al[24]4.19 ± 2.267.55 ± 4.31↓ in FEP0.56 (0.13-0.97)
Pirildar et al[25]14.2 ± 8.126.8 ± 9.3↓ in FEP1.07 (0.93-1.7)