Retrospective Study
Copyright ©The Author(s) 2015.
World J Psychiatr. Mar 22, 2015; 5(1): 126-137
Published online Mar 22, 2015. doi: 10.5498/wjp.v5.i1.126
Table 1 Mood Spectrum Structured Interview and Mood Spectrum Self-Report version studies
Ref.SubjectsDesignDiagnostic criteriaInstrumentsResults
Fagiolini et al[10]491 (141 students, 116 gastrointestinal pts, 112 pts with BPD, 122 pts with recurrent MDEs)Validation study (Italy)DSM-IVSCID-I, SCI-MOODSGood discriminant validity and internal consistency
Dell’Osso et al[11]41 (21 pts with MDEs or BPD vs 20 controls)Validation study (Italy)DSM-IVSCID-I, SCI-MOODS, MOODS-SRGood reliability of the self-report version (MOODS-SR) of the SCI-MOODS. Intraclass correlation coefficients ranged from 0.88 to 0.97
Veltri et al[34]91 pts with TMD vs 26 TMD-free subjectsOpen study (Italy)Helkimo’s Clinical Dysfunction Index (CDI), MOODS-SRTotal scores of depressive domains significantly higher in moderate or severe dysfunctional than in TMD-free and mild dysfunctional pts
Cassano et al[18]213 (117 pts with recurrent MDEs in remission and 106 pts with BP-I)Open study (Italy)DSM-IVMINI, SCI-MOODSPatients with recurrent UP depression endorsed a substantial number of manic/hypomanic symptoms over their lifetimes
Manfredini et al[35]85 subjects (34 bruxers vs 51 non-bruxers)Open Study (Italy)DSM-IVMOODS-SR, PAS-SRSignificant differences between bruxers and controls emerged for the presence of both depressive and manic symptoms in MOODS-SR
Manfredini et al[36]131 subjects screened for temporomandibular disorder (TMD)Open study (Italy)DSM-IVMOODS-SR, PAS-SR, assessment for TMDSignificantly higher prevalence of both mood and panic-agoraphobic symptoms in myofascial pain pts than in the other diagnostic groups (TMD-free, disc displacement and joint disorders)
Manfredini et al[37]20 pts with myofascial pain, 18 pts with temporomandibular joint pain-TMJ, 22 pts with combined pain vs 25 pts with non-painful TMD vs 29 TMD-free subjectsOpen study (Italy)DSM-IVMOODS-SR, PAS-SR, assessment for TMDPatients with painful TMD scored significantly higher than comparison groups in all MOODS-SR depressive domains
Cassano et al[19]39 pts with Borderline PD + BPD vs 21 pts with Borderline PDOpen study (Italy)DSM-IVSCID-I, MOODS-SR, SCID-IILifetime manic-hypomanic mood dysregulations correlated with psychotic spectrum features in borderline patients
Benvenuti et al[45]103 (70 pts with BP-I, 24 pts with BP-II, 4 pts with SA, 5 pts with BPD-NOSOpen study (United States)DSM-IVSCID-I, MOODS-SR, W-SAS, PAS-SRWSAS scores on current depressive, manic, and panic spectrum total scores showed a highly significant “depressive spectrum” effect
Dell’Osso et al[30]92 pts with Rheumatoid ArthritisOpen study (Italy)DSM-IVHAQ, MOS-SF36, MOODS-SRLifetime mood depressive spectrum was related with impaired HRQoL levels
Manfredini et al[38]105 controls with bruxing behaviorsOpen study (Italy)DSM-IVMOODS-SRPrevalence of mood psychopathology was significantly higher in bruxers. Significant differences between bruxers and non-bruxers emerged in total MOODS-SR scores
Koukopoulos et al[57]24 pts with Unipolar Depression vs 15 pts with BP-IIOpen study (Japan)DSM-IVSCI-MOODSPatients with BP-II disorder tended to show apparently quick disappearance of depressive symptoms
Ghouse et al[15]71 (49 with MDEs or BPD or GAD, 22 controls)Validation study (Spanish)DSM-IVSCID-I, BDI, MOODS-SR, Clinician-Administered Rating Scale for ManiaMOODS-SR good internal consistency and test-retest reliability. Significant positive correlations between depressive sub-domains and BDI and between manic-hypomanic subdomains and CARS for Mania
Piccinni et al[32]92 pts with Rheumatoid ArthritisOpen study (Italy)DSM-IVMOS-SF36, MOODS-SR, PAS-SRSignificant worsening of all MOS SF-36 scores related to higher scores of the depressive domains of MOODS-SR
Benvenuti et al[20]90 (25 pts with Borderline PD, 16 pts with BPD, 19 pts with MDE, 30 controls)Open study (Spanish)DSM-IVSCID-I, MOODS-SRNo statistical significance for any (sub) domain considered between patients with BPD and Bipolar Disorder
Manfredini et al[39]47 subjects (17 pts with BPD, 14 pts with MDEs, 16 controls)Open study (Italy)DSM-IVSCID-I, SCI-MOODS-SRAllopregnanolone/progesterone levels correlate with mixed features
Berrocal et al[16]598 pts with MDEOpen study (Italy + United States)DSM-IVSCID-I, MOODS-SRCentral role of depressed mood, psychomotor retardation and suicidality. The factors “Drug/Illness related depression”, “Psychotic features” and the neurovegetative dysregulation were identified
Cassano et al[17]617 pts with BPDOpen study (Italy + United States)DSM-IVSCID-I, MOODS-SR9 factors initially identified, 5 of them (Psychomotor Activation, Mixed Instability, Spirituality/Mysticism/Psychoticism, Mixed Irritability, Euphoria) subsequently retained
Dell’Osso et al[27]130 (65 pts with PTSD vs 65 controls)Open study (Italy)DSM-IVSCID-I, MOODS-SRStatistically significant and positive associations were found between the presence of manic/hypomanic and depressive symptoms and the likelihood of suicidal ideation or attempts
Dell’Osso et al[29]167 pts with fibromyalgiaOpen study (Italy)DSM-IVSCID-I, MOS-SF36, FIQ, MOODS-SRA high rate of lifetime manic symptoms was related to the Pain Visual Analogic Scale of the FIQ and the FIQ total scores and to the “bodily pain”, and to the physical and mental component scores of the MOS SF-36
Mauri et al[41]316 pts with MDEsDepression Phenotype Study: Randomized (Italy + United States)DSM-IVSCID-I, MOODS-SR, HAM-DIn patients who reached remission from an MDE according to the Hamilton Rating Scale for Depression, scores on the depressive component of the MOODS-SR predicted relapses in the subsequent 6 mo
Benazzi et al[51]222 pts with MDEsDepression Phenotype Study: Randomized (Italy + United States)DSM-IVSCID-I, MOODS-SRAssociation between the manic/hypomanic component of the MOODS-SR and the polymorphisms of the 5-HTTLPR was moderated by gender
Miniati et al[42]312 pts with MEDs (78 with a history of emotional/physical abuse, EPA)Depression Phenotype Study: Randomized (Italy + United States)DSM-IVSCID-I, SCID-II, HRSD, QIDS, MOODS-SRPatients with a history of EPA did not differ from those without on HAM-D scores at baseline. The two groups differed on factors: “dep. Mood”, “psychomotor retardation”, “drug and illness-related depression”, and “neurovegetative symptoms”
Frank et al[44]226 pts with MDEsDepression Phenotype Study: Randomized (Italy + United States)DSM-IVSCID-I, HAM-D, Q-LES-Q, WSAS, MOODS-SR, PAS-SRPoor quality of life associated with the MOODS-SR factors “depressive mood” and “psychotic features” and the PAS-SR factors “separation anxiety” and “loss sensitivity”. Functional impairment was associated with the MOODS-SR factor “psychomotor retardation” and the PAS-SR factor “fear of losing control”
Dell’Osso et al[28]48 (25 pts with PTSD vs 23 controls)Open study (Italy)DSM-IVSCID-I, IES, MOODS-SRPTSD pts showed a significant decrease in TSPO density. TSPO density correlated with the number of lifetime manic/hypomanic spectrum symptoms
Bazzichi et al[31]110 (60 pts with fibromyalgia vs 50 pts with Rheumatoid Arthritis)Open study (Italy)DSM-IVMOODS-SR (OTHERS?)FM pts showed significantly higher scores than RA patients in “mood depressive”, “cognition depressive” domains and in total depressive component
Miniati et al[43]318 pts with MDEsDepression Phenotype Study: Randomized (Italy + United States)DSM-IVSCID-I, HAM-D, MOODS-SR, PAS-SR, SHY-SRParticipants with lower scores on the MOODS-SR “psychomotor activation” factor experienced more rapid remission with SSRI
Fagiolini et al[46]291 pts with MDEsDepression Phenotype Study: Randomized (Italy + United States)DSM-IVSCID-I, SCID-II, HRSD, QIDS, MOODS-SRCompared to low scorers, participants with high scores on the LPR factor had greater severity of depression and more bipolarity indicators
Dell’Osso et al[24]103 (53 pts with complicated grief vs 50 controls)Open study (Italy)DSM-IVSCID-I, ICG, ASA-27, W-SAS, MOODS-SRPatients with CG reported significantly higher scores on the MOODS-SR, ASA-27, and WSAS with respect to controls. The scores on the ASA-27 were significantly associated with the MOODS-SR depressive and manic components
Apfelbaum et al[22]50 pts with complicated griefOpen study (Italy)DSM-IVSCID-I, ICG, MOODS-SRMOODS-SR depressive and rhythmicity/vegetative items were associated with increased suicidal ideation and attempts, while sub-threshold manic items with suicidal ideation
Rucci et al[52]1158 pts with MDEs or BPDOpen study (Italy + United States)DSM-IVSCID-I, MOODS-SRMOODS-SR psychomotor activation factor identified subgroups with an increasing likelihood of bipolar disorder diagnosis
Dell’Osso et al[25]116 (66 pts with PTSD, 22 pts with complicated grief, 28 pts with PTSD+complicated grief)Open study (Italy)SCID-I, ICG, ASA-27, W-SAS, MOODS-SRPatients with CG+PTSD or PTSD alone reported significantly higher scores on the manic component of the MOODS-SR
Dell’Osso et al[23]389 subjects (156 with Mood Disorders, 54 pts with Panic Disorder, 79 pts with schizophrenia, 100 controls)Open study (Italy)DSM-IV-TRBPRS, OBS-SR, MOODS-SR, SCID-ISexual obsessions more frequent in schizophrenia (54.4%), followed by mood disorders (35.9%), and independently associated with all aspects of suicidal behaviors
Hardoy et al[40]1066 pregnant womenProspective Study (Italy)DSM-IVSCID-I, EPDS, MOODS-SRThe prevalence of suicidality in women who had MmD during pregnancy was 26.4% and 34.1%, assessed with the MOODS-SR and the EPDS, respectively, while it was 18.4% (MOODS-SR) and 30.6% (EPDS) during the postpartum period
Berrocal et al[21]63 pts with MDE, BPD, Cluster B PD, comorbid BPD and PD-BOpen Study (United States)DSM-IVMINI and SCID II, MOODS-SR, BI, TEMPS-A and IPDEBD+PD-B pts showed a more severe type of emotional dysregulation. Patients with BD+PD-B comorbidity had an earlier onset and more severity in suicide attempts, hospitalizations and self-harm behaviors
Dell’Osso et al[26]475 studentsOpen study (Italy)DSM-IVMOODS-SR, TALS-SR (Others?)Significantly higher MOODS-SR domain scores were found in PTSD survivors compared to those without. The mood depressive, cognition depressive and energy manic MOODS-SR domains were associated with an increased likelihood of PTSD
Rucci et al[14]139 (52 pts with BP-I, 32 pts with BP-II, 17 pts with BPD-NOS vs 38 controls)Open Study (United States)DSM-IVMOODS-SR, SCID-I, GAFBPD pts scored significantly higher than controls on the total MOODS-SR scores and all sub-domains. Comparisons across BD subtypes revealed statistically significant higher scores among BD I, BD II and BD NOS only for the total MOOD-SR scores and for mood mania and energy domains