Cognitive behavioral intervention for depressive disorders in patients after cervical cancer surgery

Table 1 Baseline characteristics of patients in the two groups after propensity score matching

Variable	Observation group	Control group	t/χ2 value	P value
Age, mean ± SD	44.5 ± 8.4	46.0 ± 8.4	-1.117	0.266
Age stratification			0.264	0.870
< 40	20	22
40-59	59	56
≥ 60	5	6
Marital status			0.000	1
Married/cohabiting	63	63
Divorced/widowed/single	21	21
Educational level			0.983	0.805
Primary school and below	17	18
Junior high school	24	27
High school/technical secondary school	24	25
College level and above	19	17
Monthly household income			1.153	0.764
< 3000 yuan	18	22
3001-6000 yuan	28	27
6001-10000 yuan	23	18
> 10000 yuan	15	17
FIGO			4.281	0.118
I	49	57
II	27	25
III	8	2
Postoperative radiotherapy and chemotherapy			0.096	0.757
Yes	38	40
No	46	44
Chronic comorbidities			0.12	0.729
Yes	22	24
No	62	60
HAMD score, mean ± SD	11.2 ± 2.1	10.7 ± 2.0	1.695	0.092

FIGO: International Federation of Gynecology and Obstetrics; HAMD: Hamilton Depression Rating Scale.

Table 2 Comparison of 17-item Hamilton Depression Rating Scale scores between the two groups, mean ± SD

Variable	Observation group	Control group	t/χ2 value	P value
Baseline	11.2 ± 2.1	10.7 ± 2.0	1.695	0.092
1-month postoperative	8.7 ± 1.8	10.2 ± 2.0	-4.995	< 0.001
3-month postoperative	7.5 ± 1.5	9.6 ± 2.1	-7.337	< 0.001
6-month postoperative	6.5 ± 1.3	8.9 ± 1.9	-9.536	< 0.001
12-month postoperative	5.4 ± 1.2	8.2 ± 1.7	-12.093	< 0.001

Table 3 Comparison of depression symptom remission rate at 6 months postoperatively, n (%)

Variable	Observation group	Control group	t/χ2 value	P value
6-month postoperative
Clinical cure	43 (51.8)	4 (4.8)	45.143	< 0.001
Significant response	10 (12.0)	0	10.641	0.001

Table 4 Comparison of the incidence of depressive disorders between the two groups

Variable	Observation group	Control group	t/χ2 value	P value
1-month postoperative	22 (26.2)	31 (36.9)	2.233	0.135
3-month postoperative	18 (21.4)	35 (41.7)	7.966	< 0.01
6-month postoperative	17 (20.2)	35 (41.7)	9.024	< 0.01
12-month postoperative	15 (23.5)	32 (38.1)	8.537	< 0.01

Table 5 Comparison of Functional Assessment of Cancer Therapy-Cervix scores at 6 months postoperatively, mean ± SD

Variable	Observation group	Control group	t/χ2 value	P value
Physical status	18.0 ± 3.6	15.8 ± 3.4	4.158	< 0.001
Social/family status	25.6 ± 3.3	21.5 ± 3.3	8.149	< 0.001
Emotional status	19.6 ± 3.6	14.7 ± 3.6	8.921	< 0.001
Functional status	22.1 ± 3.4	18.1 ± 3.4	7.585	< 0.001
Cervical cancer-specific concerns	23.6 ± 3.1	19.2 ± 3.4	8.66	< 0.001

Table 6 Comparison of treatment compliance between the two groups, n (%)

Variable	Observation group	Control group	t/χ2 value	P value
			15.655	< 0.001
Complete adherence	61 (72.6)	37 (44.0)
Partial adherence	23 (27.4)	43 (51.2)
Non-adherence	0	4 (4.8)

Table 7 Multivariate logistic regression analysis for depressive disorders at 6 months postoperatively

Variable	OR value	95%CI	P value
Age	1.070	1.021-1.122	0.005
Marital status	0.804	0.328-1.970	0.632
Educational level			0.103
Monthly household income			0.632
FIGO			0.752
Postoperative radiotherapy and chemotherapy	2.995	1.337-6.708	0.008
Chronic comorbidities	0.491	0.220-1.096	0.083
CBI	0.296	0.137-0.636	0.002

FIGO: International Federation of Gynecology and Obstetrics; CBI: Cognitive behavioral intervention; OR: Odds ratio; CI: Confidence interval.