Prospective Study
Copyright ©The Author(s) 2025.
World J Psychiatry. May 19, 2025; 15(5): 103701
Published online May 19, 2025. doi: 10.5498/wjp.v15.i5.103701
Table 1 Baseline characteristics of prominent negative symptoms and non-prominent negative symptoms

n
PNS
n
Non-PNS
N
Total
Statistics
P value
Age, year, mean ± SD34332.38 ± 13.7731035.06 ± 16.8665333.66 ± 5.36t = 2.210.027a
Sex, female, n (%)343193 (56.3)310179 (57.7)653372 (57.0)χ2 = 0.140.704
Weight, kg, mean ± SD34361.62 ± 10.4431061.66 ± 10.6065361.64 ± 10.50t = 0.040.967
Height, cm, mean ± SD199166.36 ± 7.68156166.48 ± 7.24355166.41 ± 7.48t = 0.140.887
Body mass index, kg/m2, mean ± SD19922.57 ± 2.8415622.08 ± 3.1535522.35 ± 2.99t = -1.540.124
Duration of disease, month, mean ± SD34321.02 ± 56.1831013.26 ± 32.8865317.34 ± 46.72t = -2.180.030a
BPRS total score, mean ± SD34357.41 ± 14.7631037.46 ± 10.5165347.94 ± 16.31t = -20.04< 0.001b
BPRS negative symptoms subscale, mean ± SD34312.30 ± 2.953106.35 ± 1.366539.47 ± 3.78t = -33.66< 0.001b
BPRS positive symptoms subscale, mean ± SD34313.71 ± 4.233109.43 ± 3.4565311.68 ± 4.43t = -14.25< 0.001b
BPRS anxiety-depression subscale, mean ± SD34311.70 ± 4.213108.33 ± 3.5765310.10 ± 4.27t = -11.06< 0.001b
BPRS activation subscale, mean ± SD3438.10 ± 3.373105.11 ± 2.396536.68 ± 3.30t = -13.18< 0.001b
BPRS hostility-suspiciousness subscale, mean ± SD34311.59 ± 3.653108.25 ± 3.1765310.00 ± 3.81t = -12.54< 0.001b
Table 2 Adverse reactions (n = 653), n (%)
Mild
Moderate
Severe
Patients
Cases, n
Patients
Cases, n
Patients
Cases, n
Total ADRs47 (7.2)7124 (3.7)325 (0.8)5
Neurological disorders
    Akathisia24 (3.7)2512 (1.8)121 (0.2)1
    Tremor9 (1.4)96 (0.9)60 (0)0
    Dystonia7 (1.1)76 (0.9)61 (0.2)1
    Parkinsonism5 (0.8)55 (0.8)50 (0)0
Investigations
    Weight gain4 (0.6)40 (0)00 (0)0
    Increased heart rate3 (0.5)30 (0)00 (0)0
    Abnormal liver function2 (0.3)20 (0)00 (0)0
Sleep disorders5 (0.8)50 (0)00 (0)0
Gastrointestinal disorders3 (0.5)31 (0.2)10 (0)0
Kidney and urinary disorders1 (0.2)21 (0.2)11 (0.2)1