Copyright
©The Author(s) 2025.
World J Psychiatry. May 19, 2025; 15(5): 103701
Published online May 19, 2025. doi: 10.5498/wjp.v15.i5.103701
Published online May 19, 2025. doi: 10.5498/wjp.v15.i5.103701
Table 1 Baseline characteristics of prominent negative symptoms and non-prominent negative symptoms
n | PNS | n | Non-PNS | N | Total | Statistics | P value | |
Age, year, mean ± SD | 343 | 32.38 ± 13.77 | 310 | 35.06 ± 16.86 | 653 | 33.66 ± 5.36 | t = 2.21 | 0.027a |
Sex, female, n (%) | 343 | 193 (56.3) | 310 | 179 (57.7) | 653 | 372 (57.0) | χ2 = 0.14 | 0.704 |
Weight, kg, mean ± SD | 343 | 61.62 ± 10.44 | 310 | 61.66 ± 10.60 | 653 | 61.64 ± 10.50 | t = 0.04 | 0.967 |
Height, cm, mean ± SD | 199 | 166.36 ± 7.68 | 156 | 166.48 ± 7.24 | 355 | 166.41 ± 7.48 | t = 0.14 | 0.887 |
Body mass index, kg/m2, mean ± SD | 199 | 22.57 ± 2.84 | 156 | 22.08 ± 3.15 | 355 | 22.35 ± 2.99 | t = -1.54 | 0.124 |
Duration of disease, month, mean ± SD | 343 | 21.02 ± 56.18 | 310 | 13.26 ± 32.88 | 653 | 17.34 ± 46.72 | t = -2.18 | 0.030a |
BPRS total score, mean ± SD | 343 | 57.41 ± 14.76 | 310 | 37.46 ± 10.51 | 653 | 47.94 ± 16.31 | t = -20.04 | < 0.001b |
BPRS negative symptoms subscale, mean ± SD | 343 | 12.30 ± 2.95 | 310 | 6.35 ± 1.36 | 653 | 9.47 ± 3.78 | t = -33.66 | < 0.001b |
BPRS positive symptoms subscale, mean ± SD | 343 | 13.71 ± 4.23 | 310 | 9.43 ± 3.45 | 653 | 11.68 ± 4.43 | t = -14.25 | < 0.001b |
BPRS anxiety-depression subscale, mean ± SD | 343 | 11.70 ± 4.21 | 310 | 8.33 ± 3.57 | 653 | 10.10 ± 4.27 | t = -11.06 | < 0.001b |
BPRS activation subscale, mean ± SD | 343 | 8.10 ± 3.37 | 310 | 5.11 ± 2.39 | 653 | 6.68 ± 3.30 | t = -13.18 | < 0.001b |
BPRS hostility-suspiciousness subscale, mean ± SD | 343 | 11.59 ± 3.65 | 310 | 8.25 ± 3.17 | 653 | 10.00 ± 3.81 | t = -12.54 | < 0.001b |
Table 2 Adverse reactions (n = 653), n (%)
Mild | Moderate | Severe | ||||
Patients | Cases, n | Patients | Cases, n | Patients | Cases, n | |
Total ADRs | 47 (7.2) | 71 | 24 (3.7) | 32 | 5 (0.8) | 5 |
Neurological disorders | ||||||
Akathisia | 24 (3.7) | 25 | 12 (1.8) | 12 | 1 (0.2) | 1 |
Tremor | 9 (1.4) | 9 | 6 (0.9) | 6 | 0 (0) | 0 |
Dystonia | 7 (1.1) | 7 | 6 (0.9) | 6 | 1 (0.2) | 1 |
Parkinsonism | 5 (0.8) | 5 | 5 (0.8) | 5 | 0 (0) | 0 |
Investigations | ||||||
Weight gain | 4 (0.6) | 4 | 0 (0) | 0 | 0 (0) | 0 |
Increased heart rate | 3 (0.5) | 3 | 0 (0) | 0 | 0 (0) | 0 |
Abnormal liver function | 2 (0.3) | 2 | 0 (0) | 0 | 0 (0) | 0 |
Sleep disorders | 5 (0.8) | 5 | 0 (0) | 0 | 0 (0) | 0 |
Gastrointestinal disorders | 3 (0.5) | 3 | 1 (0.2) | 1 | 0 (0) | 0 |
Kidney and urinary disorders | 1 (0.2) | 2 | 1 (0.2) | 1 | 1 (0.2) | 1 |
- Citation: Chen LH, Guo Q, Hu Y, Liu XH, Hu H, Chen HY, Liu CP, Li HF, Chen JD, Li GJ. Effectiveness and safety of blonanserin monotherapy for first-episode schizophrenia with and without prominent negative symptoms: A prospective study. World J Psychiatry 2025; 15(5): 103701
- URL: https://www.wjgnet.com/2220-3206/full/v15/i5/103701.htm
- DOI: https://dx.doi.org/10.5498/wjp.v15.i5.103701