Systematic Reviews
Copyright ©The Author(s) 2021.
World J Psychiatr. May 19, 2021; 11(5): 189-200
Published online May 19, 2021. doi: 10.5498/wjp.v11.i5.189
Table 1 Time of psychological outcome measures after genetic test disclosure
Ref.
Average months after genetic test disclosure
≤ 1 mBetween 1 and 6 moMore than 6 mo
Bish et al[29], 20021YY
Claes et al[24], 20041Y
Graves et al[36], 20121Y
Lumish et al[27], 2017Y
Manne et al[22], 20041Y
O’Neill et al[20], 20061Y
O’Neill et al[6], 2009YY
Power et al[21], 2011Y
Schwartz et al[31], 20021Y
Smith et al[25], 20081YY
Table 2 Characteristics of included studies
Ref.
C country
AAim
Study design
Psychological measurements
Sample size and gene mutation status
Personal cancer history
Bish et al[29], 2002United KingdomExamine the effects of an uncertain test results affects mood and behaviorLongitudinalHADS; IES; GHQ-28; Cancer Worry ScaleTotal sample = 48. Positive = 0. Negative = 0. Inconclusive = 48History = 48. No history = 0
Claes et al[24], 2004 United StatesEvaluate the impact of a genetic test resultRetrospectiveIES; STAI; SCL-90; UCL; Semi structured-interviewTotal sample = 48. Positive = 18. Negative = 6. Inconclusive = 24History = 48. No history = 0
Graves et al[36], 2012United StatesEvaluate the long-term psychosocial impact of the genetic test resultLongitudinalIES; STAI; BSI; PSS; MICRATotal sample = 465. Positive = 144. Negative = 60. Inconclusive = 261History = 390. No history = 75
Lumish et al[27], 2017United StatesInvestigate the psychological outcomes of people who undergoing genetic testCross-sectionalIES; MICRA; SWD; AT-20Total sample = 232. Positive = 25. Negative = 173. Inconclusive = 34History = 129. No history = 103
Manne et al[22], 2004 United StatesEvaluate the distress related to undergoing the genetic testLongitudinalIES; BSI; Discussion about testing; Sharing of concerns; Comfort sharing concerns; Protective Buffering; Relationship strain; Support/encouragement for testing; Perceived negative partner behaviors.Total sample = 144. Positive = 38. Negative = 15. Inconclusive = 91History = 115. No history = 29
O’Neill et al[20], 2006 United StatesExplore psychological consequence and the tolerance of uncertain in women who receive an inconclusive test resultLongitudinalIES; BSI; MICRA; IUSTotal sample = 64. Positive = 0. Negative = 0. Inconclusive = 64History = 64. No history = 0
O’Neill et al[6], 2009United StatesAssess differences in distress levels over timeLongitudinalIES; BSI; MICRATotal sample = 209. Positive = 0. Negative = 190. Inconclusive = 19History = 209. No history = 0
Power et al[21], 2011 CanadaExamine levels of distress in people undergoing genetic testCross-sectionalHistory Questionnaire; Feelings about Test Results Measure; Psychosocial Needs Questions; BSI-18Total sample = 318. Positive = 85. Negative = 51. Inconclusive = 33. Attending result = 49. Not undergo genetic test = 100History =160. No history = 158
Schwartz et al[31], 2002 United StatesExamine the long-term psychological impact of receiving BRCA 1/2 test resultLongitudinalIES; HSCL-25Total sample = 279. Positive = 78. Negative = 58. Inconclusive = 143History = 186. No history = 93
Smith et al[25], 2008United StatesEvaluate psychological consequences of genetic test resultsLongitudinalGSI; IES; PSS; STAI; CES-D; QoLSTotal sample = 126. Positive = 20. Negative = 67. Inconclusive = 13. Not undergo genetic test = 26History = 58. No history = 68