Assessing myocardial indices and inflammatory factors to determine anxiety and depression severity in patients with chronic heart failure

Table 3 Inter-group comparison of the observed indicators of anxiety and depressive severity in patients, divided based on the requirement for early intervention

Observation indices	No/mild-A&D (N/M) (n = 107)	Moderate/severe-A&D (N/S) (n = 126)	t/Z/χ2	P value
LVEF (%, mean ± SD)	38.08 ± 3.30	36.26 ± 2.72	4.536	< 0.001
LVEDd (mm, mean ± SD)	60.46 ± 5.16	61.98 ± 4.83	2.778	0.005
NT-proBNP (ng/L, mean ± SD)	1863.13 ± 432.00	2395.81 ± 505.30	8.656	< 0.001
ST2 (μg/L, mean ± SD)	52.24 ± 10.15	53.14 ± 8.54	0.908	0.364
IL-6 (ng/L, mean ± SD)	16.12 ± 3.76	18.99 ± 4.21	5.024	< 0.001
TNF-α (ng/L, mean ± SD)	30.00 ± 6.48	34.84 ± 5.64	6.105	< 0.001
hs-CRP (ng/L, mean ± SD)	12.36 ± 2.67	13.08 ± 2.46	2.144	0.033
hs-cTn (ng/L, mean ± SD)	23.56 ± 7.89	24.44 ± 6.31	1.301	0.193

A&D: Anxiety and depression; LVEF: Left ventricular ejection fraction; LVEDd: Left ventricular end-diastolic dimension; NT-proBNP: N-terminal pro-brain natriuretic peptide; ST2: Growth stimulation expressed gene 2; IL-6: Interleukin-6; TNF-α: Tumor necrosis factor-alpha; hs-CRP: Hypersensitive C-reactive protein; hs-cTn; High sensitivity cardiac troponin; N/M: No/mild.