Assessing myocardial indices and inflammatory factors to determine anxiety and depression severity in patients with chronic heart failure

Table 1 Comparison of general patient data between the different anxiety and depression groups

Observation indices	No-A&D (n = 65)	Mild-A&D (n = 42)	Moderate-A&D (n = 93)	Severe-A&D (n = 33)	P value
Sex					0.686
Male	27 (41.54)	20 (47.61)	47 (50.54)	17 (51.52)
Female	38 (58.46)	22 (52.39)	46 (49.46)	16 (48.48)
Age (yr, mean ± SD)	63.20 ± 14.75	64.93 ± 12.81	66.08 ± 10.99	66.67 ± 12.78	0.476
Course of disease (month, mean ± SD)	68.00 ± 17.74	66.36 ± 20.49	68.53 ± 15.97	68.97 ± 20.40	0.948
NYHA, n (%)					< 0.001
I	16 (24.62)	6 (14.29)	3 (3.23)	4 (12.12)
II	27 (41.54)	8 (19.05)	26 (27.96)	8 (24.24)
III	21 (32.31)	24 (57.14)	54 (58.06)	17 (51.52)
IV	1 (1.53)	4 (9.52)	10 (10.75)	4 (12.12)
LVEF (%, mean ± SD)	38.72 ± 3.32	37.08 ± 3.03	36.24 ± 2.59	36.32 ± 3.16	< 0.001
LVEDd (mm, mean ± SD)	59.86 ± 5.22	61.38 ± 4.99	61.85 ± 4.95	62.36 ± 4.52	0.047
NT-proBNP (ng/L, mean ± SD)	1830.32 ± 421.64	1913.90 ± 447.93	2364.98 ± 490.56	2482.70 ± 541.86	< 0.001
ST2 (μg/L, mean ± SD)	51.26 ± 10.25	53.76 ± 9.92	52.97 ± 8.74	53.61 ± 8.07	0.382
IL-6 (ng/L, mean ± SD)	15.13 ± 2.98	17.66 ± 4.33	18.85 ± 3.84	19.38 ± 5.17	< 0.001
TNF-α (ng/L, mean ± SD)	28.89 ± 5.85	31.72 ± 7.08	34.68 ± 5.84	35.32 ± 5.1	< 0.001
hs-CRP (ng/L, mean ± SD)	12.27 ± 2.67	12.49 ± 2.71	13.03 ± 2.45	13.22 ± 2.54	0.185
hs-cTn (ng/L, mean ± SD)	22.94 ± 7.83	24.53 ± 7.99	24.45 ± 6.22	24.40 ± 6.67	0.293

NYHA: New York Heart Association; A&D: Anxiety and depression; LVEF: Left ventricular ejection fraction; LVEDd: Left ventricular end-diastolic dimension; NT-proBNP: N-terminal pro-brain natriuretic peptide; ST2: Growth stimulation expressed gene 2; IL-6: Interleukin-6; TNF-α: Tumor necrosis factor-alpha; hs-CRP: Hypersensitive C-reactive protein; hs-cTn: High sensitivity cardiac troponin.