Cell-free DNA in extracellular vesicles: A candidate biomarker of schizophrenia

doi:10.5498/wjp.v15.i8.107404

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Aug 19, 2025 (publication date) through Aug 11, 2025

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Psychiatry. Aug 19, 2025; 15(8): 107404
Published online Aug 19, 2025. doi: 10.5498/wjp.v15.i8.107404

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Figure 1 Sources of cell free DNA. A: Apoptosis; B: Necrosis; C: NETosis; D: Active release.

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Figure 2 The sources and application of extracellular vesicles in health and disease. Neurons and immune cells can produce extracellular vesicles (EVs) through mechanisms such as cellular apoptosis, necrosis, NETosis, and active release. The EVs generated by neurons have the capability to traverse the blood-brain barrier and enter the peripheral environment to exert their physiological effects. Furthermore, immune cells and T cells in the peripheral environment also produce EVs, which can enter the brain.

Citation: Bai YL, Ma SF, Qi DD, Guo C, Liu P, He KJ. Cell-free DNA in extracellular vesicles: A candidate biomarker of schizophrenia. World J Psychiatry 2025; 15(8): 107404
URL: https://www.wjgnet.com/2220-3206/full/v15/i8/107404.htm
DOI: https://dx.doi.org/10.5498/wjp.v15.i8.107404