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For: Li XQ, Tang XR, Li LL. Antipsychotics cardiotoxicity: What's known and what's next. World J Psychiatr 2021; 11(10): 736-753 [PMID: 34733639 DOI: 10.5498/wjp.v11.i10.736]
URL: https://www.wjgnet.com/2220-3206/full/v11/i10/736.htm
Number Citing Articles
1
Iara Ferreira, Gonçalo Carneiro, Gonçalo Sarmento, Márcia Cravo. Antipsychotic-Associated Hypothermia With Bradycardia and QT Prolongation in an Older AdultCureus 2026;  doi: 10.7759/cureus.114939
2
Ki Hong Choi, Junwoo Seo, Ji Hyun Cha, Taegyun Park, Taek Kyu Park, Joo Myung Lee, Young Bin Song, Joo-Yong Hahn, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Juhee Cho, Danbee Kang, Jeong Hoon Yang. Mental health sequelae and management in survivors of cardiogenic shock: a nationwide population-based studyCritical Care 2026; 30(1) doi: 10.1186/s13054-026-05841-0
3
Yiming Bo, Xin Zhao, Liliang Li. Cardiotoxic effects of common and emerging drugs: role of cannabinoid receptorsClinical Science 2024; 138(6) doi: 10.1042/CS20231156
4
Asdaq Shabbir Raja, Stephen J. Leslie, Elizabeth Buist, Gordon F. Rushworth, Ian L. Megson, Neil McNamara. Treating hearts and minds: adverse cardiovascular effects of psychiatric medicationsTherapeutic Advances in Drug Safety 2026; 17 doi: 10.1177/20420986261418947
5
Liliang Li, Pan Gao, Xinru Tang, Zheng Liu, Mengying Cao, Ruoyu Luo, Xiaoqing Li, Jing Wang, Xinyi Lin, Chao Peng, Zhihong Li, Jianhua Zhang, Xian Zhang, Zhonglian Cao, Yunzeng Zou, Li Jin. CB1R-stabilized NLRP3 inflammasome drives antipsychotics cardiotoxicitySignal Transduction and Targeted Therapy 2022; 7(1) doi: 10.1038/s41392-022-01018-7
6
Faizan A. Beerwala, Shruti V. Kolambkar, Adilmehadi. Karikazi, Nayeem A. Khatib, Vishwambhar V. Bhandare, Subarna Roy, Harish R. Darasaguppe. Harnessing the therapeutic potential of Garcinia indica choisy constituents against olanzapine-induced cardiac and metabolic disordersIn Silico Research in Biomedicine 2025; 1 doi: 10.1016/j.insi.2025.100010
7
Rowyna Reji Koshy, Pramodhiya Sanduni Perera, Aleena Jaxon, Reeves Thomas George, Amal Augusthy, Dino Stephen Thomas. Quetiapine in psychiatric practice: A narrative review on clinical efficacy, cardiac safety, and emerging therapeutic innovationsArchives of Biological Psychiatry 2026; 0 doi: 10.25259/ABP_28_2025
8
Ruslan A. Mirzoev, Svetlana V. Malchikova, Mikhail A. Sherman. Characteristics of the basal psychoautonomous indicators in patients after coronary artery stent placement at various stages of rehabilitationAlmanac of Clinical Medicine 2023; 51(5) doi: 10.18786/2072-0505-2023-51-031
9
Yasser Jamil, Ashok Krishnaswami, Ariela R. Orkaby, Marnina Stimmel, Charles H. Brown IV, Adam P. Mecca, Daniel E. Forman, Michael W. Rich, Michael G. Nanna, Abdulla A. Damluji. The Impact of Cognitive Impairment on Cardiovascular DiseaseJournal of the American College of Cardiology 2025; 85(25) doi: 10.1016/j.jacc.2025.04.057
10
Yu-hong Cao, Xiao-chen Wang, Hong-kun Wang, Zong-kuai Yang, Dan-dan Liu, Yang Yang, Rong Kuang, Ping Liang. ROS-induced degradation of hERG potassium channels contributes to aripiprazole-induced prolongation of the QTc intervalActa Pharmacologica Sinica 2026; 47(3) doi: 10.1038/s41401-025-01648-x
11
Ayşenur Kaya Karahan, Aslıhan Bilge Bektaş, Esin Erdogan. Olanzapine-Induced Bradycardia: A Clinical Case Reportİzmir Tıp Fakültesi Dergisi 2025; 4(4) doi: 10.57221/izmirtip.1810949
12
S.A. Galkin, E.G. Kornetova, V.F. Lebedeva, A.N. Kornetov. Search for risk factors for slowed intra-atrial conduction in patients with schizophreniaS.S. Korsakov Journal of Neurology and Psychiatry 2025; 125(11) doi: 10.17116/jnevro2025125111111
13
Fengping Yan, Fu Zhang, Yanan Yan, Le Zhang, Yuanyuan Chen. Sudden unexpected death in epilepsy: Investigation of autopsy-based studiesFrontiers in Neurology 2023; 14 doi: 10.3389/fneur.2023.1126652
14
Khalilullah Arsyi, Solaphat Hemrungrojn, Chavit Tunvirachaisakul, Derren D.C.H. Rampengan, Melissa Valentina Ariyanto, Artha M.T. Simanjuntak, Juwita Saragih. Ventricular repolarization heterogeneity in schizophrenia: A systematic review and meta-analysis of traditional and novel ECG markersAsian Journal of Psychiatry 2026; 119 doi: 10.1016/j.ajp.2026.104951
15
Emma Sheridan, Oladayo Bifarin, Maria Caves, Karen Higginbotham, Jane Harris, Julie Pinder, Peter Brame. Breaking Barriers Transforming Primary Care to Serve the Physical Health Needs of Individuals With SMI in the NHSInternational Journal of Mental Health Nursing 2025; 34(1) doi: 10.1111/inm.13480
16
Daniel W. Jones, Keith C. Ferdinand, Sandra J. Taler, Heather M. Johnson, Daichi Shimbo, Marwah Abdalla, M. Martine Altieri, Nisha Bansal, Natalie A. Bello, Adam P. Bress, Jocelyn Carter, Jordana B. Cohen, Karen J. Collins, Yvonne Commodore-Mensah, Leslie L. Davis, Brent Egan, Sadiya S. Khan, Donald M. Lloyd-Jones, Bernadette Mazurek Melnyk, Eva A. Mistry, Modele O. Ogunniyi, Stacey L. Schott, Sidney C. Smith, Amy W. Talbot, Wanpen Vongpatanasin, Karol E. Watson, Paul K. Whelton, Jeff D. Williamson. 2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice GuidelinesHypertension 2025; 82(10) doi: 10.1161/HYP.0000000000000249
17
Michael Sayer, Hirofumi Hamano, Misako Nagasaka, Benjamin J. Lee, Jean Doh, Pranav M. Patel, Yoshito Zamami, Aya F. Ozaki. Time dependent predictors of cardiac inflammatory adverse events in cancer patients receiving immune checkpoint inhibitorsCardio-Oncology 2025; 11(1) doi: 10.1186/s40959-025-00331-8
18
Adelaide Iervolino, Luigi Spadafora, Cristiano Spadaccio, Valentina Iervolino, Giuseppe Biondi Zoccai, Felicita Andreotti. Myocardial Cell Preservation from Potential Cardiotoxic Drugs: The Role of NanotechnologiesPharmaceutics 2022; 15(1) doi: 10.3390/pharmaceutics15010087
19
Juan Carlos Rivas, Juliana Galindo-A, Luis Fernando Zambrano, Carlos Alberto Miranda-B, Sandra Milena Ramírez, Ana María Rivas-Grajales, Mauricio Hernández-Carrillo, Erika Andrea Rincón, Pablo Eduardo Perafán, Juan Esteban Gómez-Mesa. Risk of corrected QT interval prolongation in patients receiving antipsychoticsInternational Clinical Psychopharmacology 2025; 40(4) doi: 10.1097/YIC.0000000000000564
20
Lakshmi Sristi, Aman Shaikh, Aafreen Kerosenewala. Safe Use of Valproate and Olanzapine for Psychotic Mania in Rheumatic Heart DiseaseAnnals of Indian Psychiatry 2026;  doi: 10.4103/aip.aip_172_25
21
Sunitha Shyam Sunder, Umesh C. Sharma, Saraswati Pokharel. Adverse effects of tyrosine kinase inhibitors in cancer therapy: pathophysiology, mechanisms and clinical managementSignal Transduction and Targeted Therapy 2023; 8(1) doi: 10.1038/s41392-023-01469-6
22
Asmaa Fady Sharif, Zahraa Khalifa Sobh, Sanaa Abd El-Fatah Abdo, Osama M. Alahmadi, Hatem A. Alharbi, Mohannad Saif Awaji, Faris A. Alabdullatif, Abdullah M. Baghlaf, Ahmad F. Alanazi, Manar Maher Fayed. Evaluation of Global Dystonia Rating Scale as a predictor of unfavorable outcomes among acute antipsychotics poisoned patientsDrug and Chemical Toxicology 2024; 47(4) doi: 10.1080/01480545.2024.2313561
23
Meghraj V. Suryawanshi, Rukaiya T. Girase, Vishal S. Bagul, Pranjal P. Gujarathi. Exploring tyrosine kinase inhibitors for HER2-positive breast cancer: comprehensive review on a complete pharmacology-molecular mechanisms, safety profiles, and insights from preclinical and clinical studiesClinical and Translational Oncology 2026; 28(9) doi: 10.1007/s12094-026-04331-7
24
Federica Folesani, Lorenzo Luviè, Cristina Palazzi, Carlo Marchesi, Rodolfo Rossi, Martino Belvederi Murri, Paolo Ossola. Psychopathology, Personality and Depression after Acute Coronary Syndrome: A Network Analysis in an Italian PopulationDiagnostics 2023; 13(5) doi: 10.3390/diagnostics13050915
25
Jiajia Chen, Guojiang Fang, Xueshi Chen, Xuefang Jiang, Yi Zhou, Liliang Li, Bing Xia. Heterogeneity and concentration-dependence of ionic channel mechanisms underlying ventricular repolarization prolongation induced by atypical antipsychoticsToxicology and Applied Pharmacology 2026; 515 doi: 10.1016/j.taap.2026.117973
26
Bradley M. Brooks, Ashley M. Nettles, Brandon M. Brooks. Diabetes Psychiatry: The Missing Piece of the Puzzle to Prevent Complications of the Diabetes PandemicPsychoactives 2025; 4(2) doi: 10.3390/psychoactives4020013
27
Mikayla Z van der Meer, Brian S Rasmussen, Michael Nedahl, Marie K K Nielsen. From blood to brain: postmortem brain concentrations and brain–blood ratios of chlorprothixene, clozapine, olanzapine, and quetiapineJournal of Analytical Toxicology 2026; 50(7) doi: 10.1093/jat/bkag065
28
Daniel W. Jones, Keith C. Ferdinand, Sandra J. Taler, Heather M. Johnson, Daichi Shimbo, Marwah Abdalla, M. Martine Altieri, Nisha Bansal, Natalie A. Bello, Adam P. Bress, Jocelyn Carter, Jordana B. Cohen, Karen J. Collins, Yvonne Commodore-Mensah, Leslie L. Davis, Brent Egan, Sadiya S. Khan, Donald M. Lloyd-Jones, Bernadette Mazurek Melnyk, Eva A. Mistry, Modele O. Ogunniyi, Stacey L. Schott, Sidney C. Smith, Amy W. Talbot, Wanpen Vongpatanasin, Karol E. Watson, Paul K. Whelton, Jeff D. Williamson. 2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice GuidelinesCirculation 2025; 152(11) doi: 10.1161/CIR.0000000000001356
29
Xue-Shi Chen, Zi-Yan Song, Xuan-Long Chen, Yi-Ming Bo, Li-Liang Li. Heart abnormality associates with a wide spectrum of psychiatric disorders: Evidence from Mendelian randomization analysesWorld Journal of Psychiatry 2024; 14(12): 1988-1991 doi: 10.5498/wjp.v14.i12.1988
30
Daniel W. Jones, Keith C. Ferdinand, Sandra J. Taler, Heather M. Johnson, Daichi Shimbo, Marwah Abdalla, M. Martine Altieri, Nisha Bansal, Natalie A. Bello, Adam P. Bress, Jocelyn Carter, Jordana B. Cohen, Karen J. Collins, Yvonne Commodore-Mensah, Leslie L. Davis, Brent Egan, Sadiya S. Khan, Donald M. Lloyd-Jones, Bernadette Mazurek Melnyk, Eva A. Mistry, Modele O. Ogunniyi, Stacey L. Schott, Sidney C. Smith, Amy W. Talbot, Wanpen Vongpatanasin, Karol E. Watson, Paul K. Whelton, Jeff D. Williamson, Donna K. Arnett, Eugene Yang, David Aguilar, Vivek Bhalla, Sarah J. Billups, Margaret Bowers, Beverly B. Green, Steven M. Greenberg, Eileen Handberg, Christopher D. Jackson, Wallace Robert Johnson, Min Ji Kwak, Renee Langstaff, Carlos Jose Rodriguez, Mark K. Santillan, Michael D. Shapiro, Prentiss Taylor, Jennifer T. Thibodeau, Gregory Wozniak, Jackson T. Wright, Wendy C. Ziai. 2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in AdultsJACC 2025; 86(18) doi: 10.1016/j.jacc.2025.05.007
31
Błażej Pilarski, Szymon Florek, Alexander Suchodolski, Mariola Szulik, Robert Pudlo. Psychopharmacological Treatment in Patients with Heart Failure: A Narrative Review of Mood Stabilizers and AntipsychoticsBrain Sciences 2026; 16(5) doi: 10.3390/brainsci16050452
32
Jing Ling Tay, Ling Zhang, Jie Sang, Keng Boon Ong. Unexpected deaths within psychiatric setting: A scoping reviewArchives of Psychiatric Nursing 2025; 56 doi: 10.1016/j.apnu.2025.151878
33
Alexandra Herlaș-Pop, Andrei-Flavius Radu, Ada Radu, Gabriela S. Bungau, Delia Mirela Tit, Elena Emilia Babes, Cristiana Bustea. The Mental Health–Acute Coronary Syndrome Continuum: Bidirectional Pathophysiological Links and Clinical ImplicationsMedical Sciences 2026; 14(1) doi: 10.3390/medsci14010138
34
Yuanyuan Chen, Fu Zhang, Yanan Yan, Shiquan Wang, Le Zhang, Fengping Yan. Sudden Cardiac Death in Schizophrenia During Hospitalization: An Autopsy-Based StudyFrontiers in Psychiatry 2022; 13 doi: 10.3389/fpsyt.2022.933025
35
Yuanyuan Chen, Fengping Yan. Forensic postmortem findings for sudden unexplained death in schizophrenia: case series and literature reviewFrontiers in Psychiatry 2026; 17 doi: 10.3389/fpsyt.2026.1578123
36
Sanja Stankovic, Nina M. Radisavljevic, Zorislava Bajic, Marija Polovina, Dragan M. Djuric. Cardiovascular ToxicityAdvances in Biochemistry in Health and Disease 2025; 33 doi: 10.1007/978-3-031-90598-8_32
37
Molin Zhang, Shouyu Wang, Xinru Tang, Xing Ye, Yongsheng Chen, Zheng Liu, Liliang Li. Use of potassium ion channel and spliceosome proteins as diagnostic biomarkers for sudden unexplained death in schizophreniaForensic Science International 2022; 340 doi: 10.1016/j.forsciint.2022.111471
38
Anne Katrine Pagsberg, Marianne Melau. Adolescent Psychosis2023;  doi: 10.1016/B978-0-323-89832-4.00002-0
39
Barbara Kramar, Tinkara Pirc Marolt, Ayse Mine Yilmaz Goler, Dušan Šuput, Irina Milisav, María Monsalve. Aripiprazole, but Not Olanzapine, Alters the Response to Oxidative Stress in Fao Cells by Reducing the Activation of Mitogen-Activated Protein Kinases (MAPKs) and Promoting Cell SurvivalInternational Journal of Molecular Sciences 2024; 25(20) doi: 10.3390/ijms252011119
40
Xuanlong Chen, Lu Ma, Yiming Bo, Bing Xia, Yadong Guo, Yanjie Shang, Fengping Yan, Erwen Huang, Weibo Shi, Runtao Ding, Hang Meng, Bi Xiao, Kaijun Ma, Liliang Li. Single-nucleus RNA sequencing and machine learning identify CACNA1A as a myocyte-specific biomarker for sudden unexplained death in schizophreniaForensic Science International 2025; 377 doi: 10.1016/j.forsciint.2025.112646
41
XueSong Zhang, SiMan Sun, XiaoYu Fan, ShuShu Guo, WanFang Li, Chuan Wang, Jia Xu, ChongZe Chen, HongTao Jin. Thromboembolic events with olanzapine: a systematic review integrating meta-analysis and FAERS databaseFrontiers in Cardiovascular Medicine 2026; 13 doi: 10.3389/fcvm.2026.1710507
42
Tomoyuki Takano. Cardiometabolic Effects of Antipsychotics in Challenging Behavior and Neuropsychiatric Symptoms in Patients With Intellectual DisabilityCureus 2023;  doi: 10.7759/cureus.48088
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Alessandro Stanca, Maria Cristina Carella, Paolo Basile, Cinzia Forleo, Marco Matteo Ciccone, Andrea Igoren Guaricci. Cardiomyopathies and Psychiatric Disorders: An Overview and General Clinical RecommendationsCardiology in Review 2026; 34(4) doi: 10.1097/CRD.0000000000000693
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Megan Young, Dunja Aksentijevic. Cardiovascular ToxicityAdvances in Biochemistry in Health and Disease 2025; 33 doi: 10.1007/978-3-031-90598-8_5
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Aleksandra Spyra, Aleksandra Sierpińska, Alexander Suchodolski, Szymon Florek, Mariola Szulik. Echocardiography with Strain Assessment in Psychiatric Diseases: A Narrative ReviewDiagnostics 2025; 15(3) doi: 10.3390/diagnostics15030239
46
Shan-Mei Liu, Qin Zhao, Wen-Jun Li, Jian-Quan Zhao. Advances in the Study of MG53 in Cardiovascular DiseaseInternational Journal of General Medicine 2023;  doi: 10.2147/IJGM.S435030
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Andreea-Violeta Popa, Petru Iulian Ifteni, Paula Simina Petric, Daniel Țâbian, Andreea Teodorescu. Trends in Sudden Death Among Schizophrenia InpatientsMedicina 2025; 61(12) doi: 10.3390/medicina61122081
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Shouyu Wang, Meng He, John Andersen, Yezhe Lin, Molin Zhang, Zheng Liu, Liliang Li. Sudden unexplained death in schizophrenia patients: An autopsy-based comparative study from ChinaAsian Journal of Psychiatry 2023; 79 doi: 10.1016/j.ajp.2022.103314
49
Haruyo Matsuo, Yoshihiro Yoshimura, Yuichi Maeno, Sayoko Tanaka. Antipsychotic use and dysphagia risk in acute heart failure: a prospective cohort studyHeart and Vessels 2026; 41(3) doi: 10.1007/s00380-025-02606-7
50
Patterson Daniel, Katta Maanya Rajaree, Luna Rudy, Sadeque Jafor, Sakshi Prasad, Chaithanya Avanthika, Sharan Jhaveri. Myocarditis in patients on long-term antipsychotics –mechanism, management and recent updatesHeliyon 2023; 9(3) doi: 10.1016/j.heliyon.2023.e13930
51
Zheng Liu, Mo-Lin Zhang, Xin-Ru Tang, Xiao-Qing Li, Jing Wang, Li-Liang Li. Cardiotoxicity of current antipsychotics: Newer antipsychotics or adjunct therapy?World Journal of Psychiatry 2022; 12(8): 1108-1111 doi: 10.5498/wjp.v12.i8.1108
52
Oluwaremilekun Zeth Tolu‐Akinnawo, Toluwalase Awoyemi, Rocio Barriga Guzman, Akhtar Naveed. Olanzapine‐induced cardiomyopathy: A mimicker of obesity cardiomyopathy?Clinical Cardiology 2024; 47(5) doi: 10.1002/clc.24278
53
Min Wang, Yixun Ma, Zefang Shen, Lufang Jiang, Xiaoyuan Zhang, Xuan Wei, Zhengqi Han, Hongxia Liu, Tiantong Yang. Mapping the Knowledge of Antipsychotics-Induced Sudden Cardiac Death: A Scientometric Analysis in CiteSpace and VOSviewerFrontiers in Psychiatry 2022; 13 doi: 10.3389/fpsyt.2022.925583
54
Grzegorz Procyk, Olga Grodzka, Marcelina Procyk, Aleksandra Gąsecka, Katarzyna Głuszek, Małgorzata Wrzosek. MicroRNAs in Myocarditis—Review of the Preclinical In Vivo TrialsBiomedicines 2023; 11(10) doi: 10.3390/biomedicines11102723
55
The Maudsley Prescribing Guidelines in Psychiatry2025;  doi: 10.1002/9781119870203.mpg001.pub2
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Alicja Gładysz, Maciej Zamorski, Agata Stebel, Julia Ligoda, Radosław Machaj, Franciszek Mach. Antipsychotic drugs and their possible cardiovascular adverse effects – literature reviewCurrent Problems of Psychiatry 2024; 25 doi: 10.12923/2353-8627/2024-0020
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Mohammed Alissa, Suad A. Alghamdi, Abdulkarim S. Binshaya, Tawfiq N. Juraybi, Awaji Y. Safhi, Amal A. Albati, Adil Abalkhail, Adel M. Alqarni. Brexpiprazole induces acute cardiotoxicity via disrupting calcineurin/NFAT and calcium signaling pathway: A validation from biochemical, echocardiographic, histological, and computational analysisTissue and Cell 2026; 100 doi: 10.1016/j.tice.2026.103340
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Arthur Tainmont. A theory on prefrontal dysfunction contributing to psychosis and other schizophrenia symptoms mediated by open potassium and hyperpolarization-activated cyclic nucleotide-gated channelsBrain Science Advances 2025; 11(2) doi: 10.26599/BSA.2024.905006
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Alessandro Cuomo, Giovanni B. Forleo, Taieb Ghodhbane, Jon Johnsen, Angel L. Montejo, Cristina Vilares Oliveira, Toby Pillinger, Jose Antonio Ramos-Quiroga, Myrto Samara, Paul H. B. Seerden, Thomas Thomas Stoeckl, Andrea Fagiolini. Physical illness in schizophrenia and the role of tolerability in antipsychotic selection: an expert consensus with a focus on cariprazineAnnals of General Psychiatry 2025; 24(1) doi: 10.1186/s12991-025-00550-4
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Ximing Chen, Dongyin Zhuo, Jiatong Zou, Haitao Song, Kaifang Yao, Hongjun Tian, Chuanjun Zhuo. Potential Mechanisms of Trimetazidine and Coenzyme Q10 Against Antipsychotic‐Induced Myocarditis: A Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation StudyCNS Neuroscience & Therapeutics 2026; 32(7) doi: 10.1002/cns.71009
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Jing Yao, Keenan Sterling, Zhe Wang, Yun Zhang, Weihong Song. The role of inflammasomes in human diseases and their potential as therapeutic targetsSignal Transduction and Targeted Therapy 2024; 9(1) doi: 10.1038/s41392-023-01687-y
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Maria Gordeeva, Irina Serdiukova, Alexander Krasichkov, Elena Parmon. Electrocardiographic Patterns of Depolarization Abnormalities Help to Identify Reduced Left Ventricular Ejection FractionDiagnostics 2022; 12(8) doi: 10.3390/diagnostics12082020
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Sahar S Abdelmoneim, Priscila Sole, Manuel De la Cruz Seoane, Ismael Palacio, Leosbel Hurtado, Pedro Valdes, Brian Valle. Cardiomyopathy Following Olanzapine Use in an Octogenarian: A Case Report and Literature ReviewCureus 2026;  doi: 10.7759/cureus.114285