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©2014 Baishideng Publishing Group Inc.
World J Pharmacol. Dec 9, 2014; 3(4): 209-216
Published online Dec 9, 2014. doi: 10.5497/wjp.v3.i4.209
Published online Dec 9, 2014. doi: 10.5497/wjp.v3.i4.209
Ref. | Study designTotal number of patients | Study population | Main outcome measure |
Chang et al[32] | Cohort-longitudinal | Korean men from a single large semiconductor company (South Korea) | Conjugated bilirubin |
n = 5900 | |||
Kwak et al[33] | Cross-section | Health check-general | |
n = 17348 | Population (South Korea) | Total bilirubin | |
Duseja et al[34] | Prospective | Hospital setting unclear, probably Tertiary (India) | Unconjugated bilirubin |
n = 67 | |||
Hjelkrem et al[35] | Retrospective | Tertiary hospital patients undergoing liver biopsy (United States) | Unconjugated bilirubin |
n = 641 | |||
Kumar et al[36] | Cross-sectional | Tertiary hospital, outpatient NAFLD clinic (India) | Unconjugated bilirubin |
n = 204 | |||
Chisholm et al[37] | Cross-sectional | Liver biopsy prior to bariatric surgery (United States) | Total bilirubin |
n = 370 | |||
Tarantino et al[38] | Cross-sectional | Tertiary hospital, outpatient likely liver clinic (Italy) | Unconjugated bilirubin |
n = 186 |
Ref. | Study analysis | Results |
Chang et al[32] | (+) Large sample (+) Prospective (-) NAFLD on US | Hazard ratio for NAFLD comparing the highest to the lower quartile of serum conjugated bilirubin = 0.61 (95%CI: 0.54-0.68), after adjusting metabolic parameters 0.86a (95%Cl : 0.76-0.98) Total bilirubin inversely associated with NAFLD OR = 0.88, 95%CI: 0.80-0.97. An inverse, dose-dependent association between NAFLD and serum total bilirubin levels OR = 0.80b, 95%CI: 0.71-0.90 in the fourth quartile vs lowest quartile |
Kwak et al[33] | (+) Large sample (-) NAFLD on US | |
Duseja et al[34] | (-) Small sample (+) Prospective (+) NASH on biopsy (selected) | Patient sample too small to make any meaningful statistical inference |
Hjelkrem et al[35] | (-)Retrospective design (-) Small sample (+) NAFLD on biopsy | Unconjugated hyperbilirubinaemia inversely associated with NASH OR = 16.1b, 95%CI: 3.7-70.8 |
Kumar et al[36] | (-) Small sample (+/-) NAFLD on biopsy but not all patients | Unconjugated hyperbilirubinaemia (UCHB) and NAS score-negative correlation: r: -0.48b. UCHB and stage of fibrosis: r: -0.28d |
Chisholm et al[37] | (-) Small sample (+) NAFLD on biopsy | Binary logistic regression showed independent association of total bilirubin with NASH cP = 0.016 Unconjugated bilirubin elevated in all spectra of NAFLD, except healthy control fP = 0.008 High UCHB in advanced NASH group |
Tarantino et al[38] | (-) Retrospective | |
(-) Small sample | ||
(+) NASH on biopsy (selected) |
- Citation: Anwar MS, Dillon JF, Miller MH. Association of serum bilirubin and non-alcoholic fatty liver disease: A feasible therapeutic avenue? World J Pharmacol 2014; 3(4): 209-216
- URL: https://www.wjgnet.com/2220-3192/full/v3/i4/209.htm
- DOI: https://dx.doi.org/10.5497/wjp.v3.i4.209