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World J Med Genet. Nov 27, 2014; 4(4): 105-109
Published online Nov 27, 2014. doi: 10.5496/wjmg.v4.i4.105
Preimplantation HLA typing: Practical tool for stem cell transplantation treatment of congenital disorders
Anver Kuliev, Svetlana Rechitsky
Anver Kuliev, Svetlana Rechitsky, Reproductive Genetics Institute, Chicago, IL 60657, United States
Author contributions: Kuliev A and Rechitsky S contributed equally to this work, generated the design and wrote the manuscript.
Correspondence to: Anver Kuliev, MD, PhD, Reproductive Genetics Institute, 2825 N Halsted St, Chicago, IL 60657, United States. anverkuliev@hotmail.com
Telephone: +1-847-4001515 Fax: +1-847-4001516
Received: March 28, 2014
Revised: July 11, 2014
Accepted: August 27, 2014
Published online: November 27, 2014
Abstract

It is well known that to achieve an acceptable engraftment and survival in stem cell therapy, an human leukocyte antigens (HLA) identical stem cell transplant is strongly required. However, the availability of the HLA matched donors even among family members is extremely limited, so preimplantation HLA typing provides an attractive practical tool of stem cell therapy for children requiring HLA matched stem cell transplantation. The present experience of preimplantation genetic diagnosis (PGD) for HLA typing of over one thousand cases shows that PGD provides the at-risk couples with the option to establish an unaffected pregnancy, which may benefit the affected member of the family with hemoglobinopathies, immunodeficiencies and other congenital or acquired bone marrow failures. Despite ethical issues involved in preimplantation HLA typing, the data presented below show an extremely high attractiveness of this option for the couples with affected children requiring HLA compatible stem cell transplantation.

Keywords: Preimplantation HLA typing, Preimplantation genetic diagnosis, Stem cell transplantation, Hemoglobinopathies, Immunodeficiencies, Aneuploidy testing

Core tip: Human leukocyte antigens (HLA) identical stem cell transplant is the key in achieving an acceptable engraftment and survival in stem cell therapy. However, the availability of the HLA matched donors even among family members is extremely limited, so preimplantation HLA typing provides an attractive practical tool of stem cell therapy for children requiring HLA matched stem cell transplantation.