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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Clin Infect Dis. Nov 25, 2014; 4(4): 27-40
Published online Nov 25, 2014. doi: 10.5495/wjcid.v4.i4.27
Published online Nov 25, 2014. doi: 10.5495/wjcid.v4.i4.27
Subversion of cellular stress responses by poxviruses
Thiago Lima Leão, Flávio Guimarães da Fonseca, Laboratório de Virologia Básica e Aplicada, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270-901, Brasil
Author contributions: Leão TL and da Fonseca FG were responsible for the writing and preparation of the article; no writing assistance was utilized in the production of this manuscript.
Supported by CAPES, CNPq, FAPEMIG and INCTV
Correspondence to: Flávio Guimarães da Fonseca, MSc, PhD, Laboratório de Virologia Básica e Aplicada, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais. Av. Antônio Carlos 6627, Belo Horizonte, MG 31270-901, Brasi. fdafonseca@icb.ufmg.br
Telephone: +55-31-34092746 Fax: +55-31-34092733
Received: June 29, 2014
Revised: July 26, 2014
Accepted: September 4, 2014
Published online: November 25, 2014
Revised: July 26, 2014
Accepted: September 4, 2014
Published online: November 25, 2014
Core Tip
Core tip: Poxviruses are known to encode a plethora of proteins that interact with cell biology processes in order to achieve replicative success. In this article, we review how poxviruses cope with cellular stress signals that are usually triggered upon infection to tentatively block virus replication. The understanding of mechanisms by which poxviruses and other complex viruses interfere with stress responses can further illuminate the web of pathways regulating cell homeostasis, as well as how viruses intertwine their own biochemical needs into this intricate scenario.