Monkeypox in neonates: A narrative review on clinical presentations, vertical transmission, and treatment challenges

doi:10.5495/wjcid.v14.i1.109806

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Jul 25, 2025 (publication date) through Jul 27, 2025

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World Journal of Clinical Infectious Diseases

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2220-3176

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Infect Dis. Jul 25, 2025; 14(1): 109806
Published online Jul 25, 2025. doi: 10.5495/wjcid.v14.i1.109806

Monkeypox in neonates: A narrative review on clinical presentations, vertical transmission, and treatment challenges

Ezza Ikram, Abaidullah Shaukat, Muhammad Shoaib Qureshi, Muneeb Saifullah, M Afaq Aslam, Abbas Muhammad Mehdi

Ezza Ikram, Abaidullah Shaukat, M Afaq Aslam, Department of Medicine, Quaid-e-Azam Medical College, Bahawalpur, Bhawana 63100, Punjab, Pakistan

Muhammad Shoaib Qureshi, Muneeb Saifullah, Department of Medicine, King Edward Medical University, Lahore 54000, Punjab, Pakistan

Abbas Muhammad Mehdi, Department of Medicine, International School of Medicine International University of Kyrgyzstan, Bishkek 720065, Kyrgyzstan

Author contributions: Ikram E and Shaukat A conceived and revised the manuscript; Qureshi MS, Saifullah M, Aslam MA and Mehdi AM wrote and reviewed the manuscript; and all authors thoroughly reviewed and endorsed the final manuscript.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Abbas Muhammad Mehdi, MD, Department of Medicine, International School of Medicine International University of Kyrgyzstan, 6 Seven April Street, Bishkek 720065, Kyrgyzstan. malikmehdi0508@gmail.com

Received: May 22, 2025
Revised: June 14, 2025
Accepted: July 9, 2025
Published online: July 25, 2025
Processing time: 63 Days and 10.2 Hours

Core Tip

Core Tip: Neonatal Monkeypox, though rare, presents significant diagnostic and therapeutic challenges due to limited data and clinical overlap with other infections. Vertical and perinatal transmission pathways raise concerns for early-life vulnerability. This review highlights the urgent need for age-specific antiviral protocols and evidence-based guidelines for neonatal management.