Published online May 21, 2019. doi: 10.5495/wjcid.v9.i1.1
Peer-review started: January 3, 2019
First decision: March 15, 2019
Revised: March 29, 2019
Accepted: April 8, 2019
Article in press: April 9, 2019
Published online: May 21, 2019
Methicillin-resistant Staphylococcus aureus (MRSA) has remained a major threat to healthcare; in both hospital and community settings over the past five decades. With the current use of antibiotics for a variety of infections, including MRSA, emerging resistance is a major concern. Currently available treatments have restrictions limiting their use. These issues include, but are not limited to, side effects, cross-resistance, lack of understanding of pharmacokinetics and clinical pharmacodynamics, gradual increment in minimal inhibitory concentration over the period (MIC creep) and ineffectiveness in dealing with bacterial biofilms. Despite availability of various therapeutic options for MRSA, the clinical cure rates remain low with high morbidity and mortality. Given these challenges with existing treatments, there is a need for development of novel agents for MRSA. Along with prompt infection control strategies and strict implementation of antibiotic stewardship, cautious use of newer anti-MRSA agents will be of utmost importance. This article reviews the treatments and limitations of MRSA management and highlights the future path.
Core tip: Methicillin-resistant S. aureus (MRSA) remains a major threat despite availability of multiple treatments. Limitations of the current anti-MRSA treatments demand more careful use of these agents. Using antibiotics in combination for MRSA treatment needs further evaluation. Multiple strategies including research and development of new antibiotics and antibiotic stewardship are necessary to contain the MRSA.