Letter to the Editor
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Infect Dis. Oct 28, 2020; 10(4): 55-57
Published online Oct 28, 2020. doi: 10.5495/wjcid.v10.i4.55
Top ten tips for perfect corona-2 prophylaxis
Ahmad Abul-Ainine, Ali A Sadek
Ahmad Abul-Ainine, Consultant Paediatrician, Paediatric Department, Thuwal, Jeddah 23955, Saudi Arabia
Ali A Sadek, Consultant Public Health and Medical Statistics, MOH, Kuwait
Author contributions: Abul-Ainine A wrote the manuscript, revised it, made the dosing software, and made the submission; Sadek AA discussed all items principles, reviewed and corrected the manuscript and tested the software.
Conflict-of-interest statement: The authors have no any conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Ahmad Abul-Ainine, CCST, FRCP, Consultant Paediatrician, Paediatric Department, Thuwal, Jeddah 23955, Saudi Arabia. ainine@doctors.net.uk
Received: June 11, 2020
Peer-review started: June 11, 2020
First decision: July 4, 2020
Revised: August 2, 2020
Accepted: September 18, 2020
Article in press: September 18, 2020
Published online: October 28, 2020
Abstract

The current corona-2 pandemic has stimulated wide research for hydroxychloroquine (Quine) therapy and lately, prophylaxis. To optimize prophylaxis proper methods of use are explained. The focus is on tools of assessment and robust comparison; defining infection objectively; loading and maintenance dose designing based on pharmaco-viro-kinetics; confirming Quine threshold-levels and its sufficiency; and Quine side-effects vigilance/ amelioration. Attention to statistics to study valid endpoints of goals in appropriately-sized population is essential. Mass interactive quine dose auto designer software is built to simplify, optimize and help collaboration of complex Quine dosing system. A similar chloroquine software can be built.

Keywords: Corona-2, COVID-19, Hydroxychloroquine, Prophylaxis, Dose, Mass interactive quine dose auto designer

Core Tip: Quine's role in corona-2 pandemic prophylaxis can be assured via designing correct loading doses (LD)/ maintenance doses (MD), therapy duration, and volumetric absorptive microsampling (VAMS) concentrations, assuring human IC50 and Liver and Heart safety thresholds of TCL10 and TCH10. Surely, good care will translate VeroE6 Viro-kinetics into human Viro-kinetics and help human-tailored dosing; not misguided by improper models, malaria, or rheumatology doses. Mass interactive quine dose auto designer (MIQDAD), viral count, and VAMS test help initial Quine LD/MD designing and human-tailored LD/MD dosing.