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World J Hypertens. Mar 22, 2023; 11(1): 1-11
Published online Mar 22, 2023. doi: 10.5494/wjh.v11.i1.1
Role of major adipokines in hypertension: A literature review
Saira Rafaqat, Sobia Nasreen, Sana Rafaqat
Saira Rafaqat, Sobia Nasreen, Department of Zoology, Lahore College for Women University, Lahore 54000, Pakistan
Sana Rafaqat, Department of Biotechnology, Lahore College for Women University, Lahore 54000, Pakistan
Author contributions: Rafaqat S carried out the study design and data collection; Rafaqat S and Rafaqat S wrote the manuscript; Nasreen S gave the editing services of the manuscript; all authors read and approved the final manuscript.
Conflict-of-interest statement: All the authors declared no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Saira Rafaqat, PhD, Lecturer, Department of Zoology, Lahore College for Women University, Near Wapda Flats Jail Road, Jubilee Town, Lahore 54000, Pakistan.
Received: November 26, 2022
Peer-review started: November 26, 2022
First decision: January 31, 2023
Revised: February 11, 2023
Accepted: March 6, 2023
Article in press: March 6, 2023
Published online: March 22, 2023
Core Tip

Core Tip: Many studies have reported the role of adipokines in hypertension. Adipocytes and their variety of factors make contributions to the long-term regulation of blood pressure. The risk of hypertension and cardiovascular diseases increase due to obesity mainly central obesity. However, this review article only focuses on the major adipokines such as chemerin, visfatin, retinol-binding protein 4, plasminogen activator inhibitor-1, monocyte chemotactic protein-1, omentin-1, lipocalin-2, vaspin, progranulin, complement C1q tumor necrosis factor-related proteins, and nesfatin-1 role in hypertension which were not reported collectively. Further studies require to find the exact mechanism of action of these adipokines in hypertensive subjects and therapeutic approaches are required to control the increasing prevalence of hypertension with obesity, which ultimately reduces the incidence of obesity-associated hypertension and cardiovascular diseases.