Suzuki JI, Aoyama N. Influence of periodontitis on abdominal aortic aneurysms. World J Hypertens 2014; 4(3): 25-28 [DOI: 10.5494/wjh.v4.i3.25]
Corresponding Author of This Article
Jun-ichi Suzuki, MD, PhD, Department of Advanced Clinical Science and Therapeutics, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8655, Japan. junichisuzuki-circ@umin.ac.jp
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Minireviews
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World J Hypertens. Aug 23, 2014; 4(3): 25-28 Published online Aug 23, 2014. doi: 10.5494/wjh.v4.i3.25
Influence of periodontitis on abdominal aortic aneurysms
Jun-ichi Suzuki, Norio Aoyama
Jun-ichi Suzuki, Department of Advanced Clinical Science and Therapeutics, The University of Tokyo, Tokyo 113-8655, Japan
Norio Aoyama, Department of Periodontology, Tokyo Medical and Dental University, Tokyo 113-8549, Japan
Author contributions: Suzuki J and Aoyama N analyzed the data and wrote the paper.
Supported by Mitsui Life Social Welfare Foundation, Daiwa Security Health Foundation, Mitsui Sumitomo Marine Welfare Foundation, Institute of Geriatric Dentistry Foundation, Institute of St. Luka Life Science Foundation, Health Welfare Foundation, Taiyo Life Welfare Foundation, the 8020 Foundation, Terumo Science Foundation, Pfizer Health Research Foundation, and General Health Promotion Foundation
Correspondence to: Jun-ichi Suzuki, MD, PhD, Department of Advanced Clinical Science and Therapeutics, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8655, Japan. junichisuzuki-circ@umin.ac.jp
Telephone: +81-3-58009116 Fax: +81-3-58009182
Received: June 26, 2014 Revised: July 15, 2014 Accepted: August 20, 2014 Published online: August 23, 2014
Abstract
Periodontitis is known to be a risk factor for abdominal aortic aneurysm (AAA). However, the influence of periodontitis on AAA development is to be elucidated. This article is to review the relationship between periodontitis and AAA. We focused on the roles of specific periodontopathic bacteria in AAA, matrix metalloproteinases and toll-like receptors in the pathophysiology in the section of experimental analysis. Furthermore, we showed clinical data of periodontitis in patients with AAA. We concluded that periodontal pathogens play a critical role in the AAA development.
Core tip: This article is to review the relationship between periodontitis and abdominal aortic aneurysm. We showed experimental and clinical data to demonstrate the relationship. We concluded that the infection of periodontal pathogens is critical in the aneurysm development.
